Poly(lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine

Se Na Kim, Byeong Hyeon Choi, Hyun Koo Kim, Young Bin Choy

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

To control postoperative pain, a bolus solution of anesthetic drugs is often injected locally, which, however, is limited by short-term drug efficacy and low bioavailability. To resolve this, we propose a composite formulation of bupivacaine-loaded poly(lactic-co-glycolic acid) microparticles (BPC-MPs) and fibrin glue. We prepared the BPC-MPs using the emulsion method and formulated them with fibrin glue to produce FG_BPC-MPs. We performed in vitro drug release experiments for 35 days with the formulations in pH 7.4 phosphate buffered saline (PBS) at 37 ℃. To evaluate in vivo pain-relief efficacy, the pain-induced animals via L5-spinal nerve ligation were treated with FG_BPC-MPs, as well as the control formulations, and the paw withdrawal latency was evaluated with the von Frey filament test. The FG_BPC-MPs exhibited a sustained drug release with a reduced initial burst for up to 35 days. When tested in vivo, a dramatic increase in paw withdrawal threshold was observed during the entire 10-day testing period, suggesting that the pain-relief efficacy was improved and prolonged compared with that for the other control formulations. The FG_BPC-MPs loaded with bupivacaine can be a promising formulation for the treatment of local, persistent pain after surgery.

Original languageEnglish
Pages (from-to)86-92
Number of pages7
JournalJournal of Industrial and Engineering Chemistry
Volume75
DOIs
StatePublished - 25 Jul 2019

Fingerprint

Fibrin Tissue Adhesive
Glues
Bupivacaine
Acids
Anesthetics
Pharmaceutical Preparations
Surgery
Emulsions
Animals
Phosphates
polylactic acid-polyglycolic acid copolymer
Milk
Composite materials
Testing
Experiments

Keywords

  • Bupivacaine
  • Fibrin glue
  • Local anesthetic
  • Microparticles
  • Sustained delivery

Cite this

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title = "Poly(lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine",
abstract = "To control postoperative pain, a bolus solution of anesthetic drugs is often injected locally, which, however, is limited by short-term drug efficacy and low bioavailability. To resolve this, we propose a composite formulation of bupivacaine-loaded poly(lactic-co-glycolic acid) microparticles (BPC-MPs) and fibrin glue. We prepared the BPC-MPs using the emulsion method and formulated them with fibrin glue to produce FG_BPC-MPs. We performed in vitro drug release experiments for 35 days with the formulations in pH 7.4 phosphate buffered saline (PBS) at 37 ℃. To evaluate in vivo pain-relief efficacy, the pain-induced animals via L5-spinal nerve ligation were treated with FG_BPC-MPs, as well as the control formulations, and the paw withdrawal latency was evaluated with the von Frey filament test. The FG_BPC-MPs exhibited a sustained drug release with a reduced initial burst for up to 35 days. When tested in vivo, a dramatic increase in paw withdrawal threshold was observed during the entire 10-day testing period, suggesting that the pain-relief efficacy was improved and prolonged compared with that for the other control formulations. The FG_BPC-MPs loaded with bupivacaine can be a promising formulation for the treatment of local, persistent pain after surgery.",
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Poly(lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine. / Kim, Se Na; Choi, Byeong Hyeon; Kim, Hyun Koo; Choy, Young Bin.

In: Journal of Industrial and Engineering Chemistry, Vol. 75, 25.07.2019, p. 86-92.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Poly(lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine

AU - Kim, Se Na

AU - Choi, Byeong Hyeon

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AU - Choy, Young Bin

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AB - To control postoperative pain, a bolus solution of anesthetic drugs is often injected locally, which, however, is limited by short-term drug efficacy and low bioavailability. To resolve this, we propose a composite formulation of bupivacaine-loaded poly(lactic-co-glycolic acid) microparticles (BPC-MPs) and fibrin glue. We prepared the BPC-MPs using the emulsion method and formulated them with fibrin glue to produce FG_BPC-MPs. We performed in vitro drug release experiments for 35 days with the formulations in pH 7.4 phosphate buffered saline (PBS) at 37 ℃. To evaluate in vivo pain-relief efficacy, the pain-induced animals via L5-spinal nerve ligation were treated with FG_BPC-MPs, as well as the control formulations, and the paw withdrawal latency was evaluated with the von Frey filament test. The FG_BPC-MPs exhibited a sustained drug release with a reduced initial burst for up to 35 days. When tested in vivo, a dramatic increase in paw withdrawal threshold was observed during the entire 10-day testing period, suggesting that the pain-relief efficacy was improved and prolonged compared with that for the other control formulations. The FG_BPC-MPs loaded with bupivacaine can be a promising formulation for the treatment of local, persistent pain after surgery.

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