Plaque modification and stabilization after paclitaxel-coated balloon treatment for de novo coronary lesions

Ae Young Her, Eun Seok Shin, Ju Hyun Chung, Yong Hoon Kim, Scot Garg, Joo Myung Lee, Joon Hyung Doh, Chang Wook Nam, Bonkwon Koo

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This study aimed to assess the healing response, as evidenced through temporal morphological and functional changes, following paclitaxel-coated balloon (PCB) treatment of de novo coronary lesions. This retrospective, observational study, included patients with significant de novo coronary lesions who were treated with PCB and had serial angiographic, intravascular ultrasound virtual histology (IVUS-VH), fractional flow reserve (FFR) measurements, and optical coherence tomography (OCT) performed before balloon angioplasty (BA), after BA, and at 9-month follow-up. A total of 20 patients (21 lesions) were included in this study. After PCB treatment, IVUS showed significant increases in the mean vessel area (12.0 ± 2.2 mm2 to 13.8 ± 2.5 mm2, p = 0.023), and mean lumen area (5.6 ± 1.2 mm2 to 7.0 ± 1.5 mm2, p = 0.003). Coronary flow was restored after BA with an FFR value of 0.87 ± 0.04 which was sustained at 9-month follow-up with no significant decrease (0.83 ± 0.08, p = 0.329). Serial OCT analysis showed that at 9-month follow-up dissections after BA sealed in 14 lesions (67%), whilst the macrophages decreased from 10 (50%) to 7 (35%) lesions, and the cap thickness of plaque increased from 0.12 ± 0.06 mm to 0.17 ± 0.09 mm (p = 0.007). PCB treatment for de novo coronary lesions showed persistent anatomical and functional patency at mid-term follow-up. Plaque modification, vascular remodeling, and plaque stabilization were also observed during follow-up.

Original languageEnglish
Pages (from-to)1113-1121
Number of pages9
JournalHeart and Vessels
Volume34
Issue number7
DOIs
StatePublished - 12 Jul 2019

Fingerprint

Balloon Angioplasty
Paclitaxel
Optical Coherence Tomography
Therapeutics
Observational Studies
Dissection
Histology
Retrospective Studies
Macrophages

Keywords

  • De novo coronary lesions
  • Fractional flow reserve
  • Optical coherence tomography
  • Paclitaxel-coated balloon
  • Vessel remodeling

Cite this

Her, Ae Young ; Shin, Eun Seok ; Chung, Ju Hyun ; Kim, Yong Hoon ; Garg, Scot ; Lee, Joo Myung ; Doh, Joon Hyung ; Nam, Chang Wook ; Koo, Bonkwon. / Plaque modification and stabilization after paclitaxel-coated balloon treatment for de novo coronary lesions. In: Heart and Vessels. 2019 ; Vol. 34, No. 7. pp. 1113-1121.
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abstract = "This study aimed to assess the healing response, as evidenced through temporal morphological and functional changes, following paclitaxel-coated balloon (PCB) treatment of de novo coronary lesions. This retrospective, observational study, included patients with significant de novo coronary lesions who were treated with PCB and had serial angiographic, intravascular ultrasound virtual histology (IVUS-VH), fractional flow reserve (FFR) measurements, and optical coherence tomography (OCT) performed before balloon angioplasty (BA), after BA, and at 9-month follow-up. A total of 20 patients (21 lesions) were included in this study. After PCB treatment, IVUS showed significant increases in the mean vessel area (12.0 ± 2.2 mm2 to 13.8 ± 2.5 mm2, p = 0.023), and mean lumen area (5.6 ± 1.2 mm2 to 7.0 ± 1.5 mm2, p = 0.003). Coronary flow was restored after BA with an FFR value of 0.87 ± 0.04 which was sustained at 9-month follow-up with no significant decrease (0.83 ± 0.08, p = 0.329). Serial OCT analysis showed that at 9-month follow-up dissections after BA sealed in 14 lesions (67{\%}), whilst the macrophages decreased from 10 (50{\%}) to 7 (35{\%}) lesions, and the cap thickness of plaque increased from 0.12 ± 0.06 mm to 0.17 ± 0.09 mm (p = 0.007). PCB treatment for de novo coronary lesions showed persistent anatomical and functional patency at mid-term follow-up. Plaque modification, vascular remodeling, and plaque stabilization were also observed during follow-up.",
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Plaque modification and stabilization after paclitaxel-coated balloon treatment for de novo coronary lesions. / Her, Ae Young; Shin, Eun Seok; Chung, Ju Hyun; Kim, Yong Hoon; Garg, Scot; Lee, Joo Myung; Doh, Joon Hyung; Nam, Chang Wook; Koo, Bonkwon.

In: Heart and Vessels, Vol. 34, No. 7, 12.07.2019, p. 1113-1121.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Shin, Eun Seok

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AU - Lee, Joo Myung

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