Periodicity of cerebral flow velocity during sleep and its association with white-matter hyperintensity volume

Woo Jin Lee, Keun Hwa Jung, Hyun Min Park, Chul Ho Sohn, Soon Tae Lee, Kyung Il Park, Kon Chu, Ki Young Jung, Manho Kim, Sang Kun Lee, Jae Kyu Roh

Research output: Contribution to journalArticle

Abstract

Impaired sleep-related activation of the cerebral waste-clearance system might be related with the brain aging process. We hypothesized that cerebral blood-flow pattern changes during sleep might reflect the activation of the cerebral waste-clearance system and investigated its association with the cerebral white-matter hyperintensity (WMH) volume. Fifty healthy volunteers were prospectively recruited. In addition to the baseline transcranial Doppler parameters, the mean flow velocity (MFV) of the middle cerebral artery was monitored during waking and short-term non-REM sleep. Spectral density analysis was performed to analyze the periodic MFV variation patterns. For the aged subgroup (>50 years, n = 25), the WMH volumes in the total, subcortical, and periventricular regions were measured. The MFV periodic pattern during sleep was substantially augmented over that in the waking status. Spectral density analysis of MFV showed a noticeable peak in the very-low–frequency (VLF) band during sleep status (sleep/waking ratio 2.87 ± 2.71, P < 0.001). In linear regression analysis in the aged subgroup, the sleep/waking ratio of the VLF peak was inversely associated with total (P = 0.013) and subcortical (P = 0.020) WMH volumes. Sleep-related amplification of the cerebral flow-velocity periodicity might reflect the activation of cerebral waste clearance system during sleep, and be related to the pathogenesis of cerebral WMH.

Original languageEnglish
Article number15510
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Periodicity
Sleep
Cerebrovascular Circulation
White Matter
Middle Cerebral Artery
Linear Models
Healthy Volunteers
Regression Analysis
Brain

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Lee, Woo Jin ; Jung, Keun Hwa ; Park, Hyun Min ; Sohn, Chul Ho ; Lee, Soon Tae ; Park, Kyung Il ; Chu, Kon ; Jung, Ki Young ; Kim, Manho ; Lee, Sang Kun ; Roh, Jae Kyu. / Periodicity of cerebral flow velocity during sleep and its association with white-matter hyperintensity volume. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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Periodicity of cerebral flow velocity during sleep and its association with white-matter hyperintensity volume. / Lee, Woo Jin; Jung, Keun Hwa; Park, Hyun Min; Sohn, Chul Ho; Lee, Soon Tae; Park, Kyung Il; Chu, Kon; Jung, Ki Young; Kim, Manho; Lee, Sang Kun; Roh, Jae Kyu.

In: Scientific Reports, Vol. 9, No. 1, 15510, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Lee, Woo Jin

AU - Jung, Keun Hwa

AU - Park, Hyun Min

AU - Sohn, Chul Ho

AU - Lee, Soon Tae

AU - Park, Kyung Il

AU - Chu, Kon

AU - Jung, Ki Young

AU - Kim, Manho

AU - Lee, Sang Kun

AU - Roh, Jae Kyu

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