Pathogenesis of recalcitrant chronic rhinosinusitis

The emerging role of innate immune cells

Il Gyu Kong, Dae Woo Kim

Research output: Contribution to journalReview articleResearchpeer-review

1 Citation (Scopus)

Abstract

Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.

Original languageEnglish
Article numbere6
JournalImmune Network
Volume18
Issue number2
DOIs
StatePublished - 1 Apr 2018

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Research
Eosinophils
Neutrophils
Epithelial Cells
Macrophages
Lymphocytes
T-Lymphocytes
Phenotype

Keywords

  • Chronic rhinosinusitis
  • Innate immune cell
  • Nasal polyps
  • Pathogenesis
  • Recalcitrant chronic rhinosinusitis

Cite this

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title = "Pathogenesis of recalcitrant chronic rhinosinusitis: The emerging role of innate immune cells",
abstract = "Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.",
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Pathogenesis of recalcitrant chronic rhinosinusitis : The emerging role of innate immune cells. / Kong, Il Gyu; Kim, Dae Woo.

In: Immune Network, Vol. 18, No. 2, e6, 01.04.2018.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Kim, Dae Woo

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KW - Chronic rhinosinusitis

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