Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts

Byung Mi Kim, Mei Huei Chen, Pau Chung Chen, Hyesook Park, Mina Ha, Yangho Kim, Yun-Chul Hong, Young Ju Kim, Eun Hee Ha

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Prospective cohort studies of the effect of mercury (Hg) exposure on birth weight have shown conflicting results. We combined data from Taiwanese and Korean birth cohorts, and assessed the effects of Hg exposure on birth weight. The first cohort was drawn from the Mothers and Children's Environmental Health (MOCEH) study performed in Korea from 2006 to 2010. The second cohort was enrolled from 2004 to 2005 and included singleton term births from the Taiwan Birth Panel Study (TBPS). In total, 1147 pregnant women were included in this study. A pooled analysis was performed to obtain combined estimates of the association between prenatal total Hg exposure and birth weight. A significant negative association between maternal and cord blood Hg and birth weight in the high-Hg group (Hg level > 25th percentile) was detected (maternal blood: β = − 0.056; 95% CI, − 0.100 to − 0.013, cord blood: β = − 0.075; 95% CI, − 0.121 to − 0.028). Hg level showed a negative coefficient in the path analysis, indicating an adverse effect on birth weight (total effects: β = − 0.177, P = 0.01 in MOCEH, β = − 0.204, P = 0.03 in TBPS), but fish consumption exhibited a strong positive coefficient. In addition, fish consumption exerted a significant indirect effect on birth weight through exposure to cord blood Hg. Exposure to hazardous contaminants and beneficial nutrients may be highly correlated in those who frequently consume fish. Moreover, Hg in cord blood may adversely affect birth weight.

Original languageEnglish
Pages (from-to)1003-1010
Number of pages8
JournalScience of the Total Environment
Volume605-606
DOIs
StatePublished - 15 Dec 2017

Fingerprint

path analysis
Mercury
Blood
Fish
blood
Health
fish
Nutrients
mercury
Impurities
exposure
effect
pollutant
nutrient

Keywords

  • Birth weight
  • Cohort
  • Korea
  • Mercury
  • Prenatal exposure
  • Taiwan

Cite this

Kim, Byung Mi ; Chen, Mei Huei ; Chen, Pau Chung ; Park, Hyesook ; Ha, Mina ; Kim, Yangho ; Hong, Yun-Chul ; Kim, Young Ju ; Ha, Eun Hee. / Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts. In: Science of the Total Environment. 2017 ; Vol. 605-606. pp. 1003-1010.
@article{dcf26da8e0444117914af258396a9a37,
title = "Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts",
abstract = "Prospective cohort studies of the effect of mercury (Hg) exposure on birth weight have shown conflicting results. We combined data from Taiwanese and Korean birth cohorts, and assessed the effects of Hg exposure on birth weight. The first cohort was drawn from the Mothers and Children's Environmental Health (MOCEH) study performed in Korea from 2006 to 2010. The second cohort was enrolled from 2004 to 2005 and included singleton term births from the Taiwan Birth Panel Study (TBPS). In total, 1147 pregnant women were included in this study. A pooled analysis was performed to obtain combined estimates of the association between prenatal total Hg exposure and birth weight. A significant negative association between maternal and cord blood Hg and birth weight in the high-Hg group (Hg level > 25th percentile) was detected (maternal blood: β = − 0.056; 95{\%} CI, − 0.100 to − 0.013, cord blood: β = − 0.075; 95{\%} CI, − 0.121 to − 0.028). Hg level showed a negative coefficient in the path analysis, indicating an adverse effect on birth weight (total effects: β = − 0.177, P = 0.01 in MOCEH, β = − 0.204, P = 0.03 in TBPS), but fish consumption exhibited a strong positive coefficient. In addition, fish consumption exerted a significant indirect effect on birth weight through exposure to cord blood Hg. Exposure to hazardous contaminants and beneficial nutrients may be highly correlated in those who frequently consume fish. Moreover, Hg in cord blood may adversely affect birth weight.",
keywords = "Birth weight, Cohort, Korea, Mercury, Prenatal exposure, Taiwan",
author = "Kim, {Byung Mi} and Chen, {Mei Huei} and Chen, {Pau Chung} and Hyesook Park and Mina Ha and Yangho Kim and Yun-Chul Hong and Kim, {Young Ju} and Ha, {Eun Hee}",
year = "2017",
month = "12",
day = "15",
doi = "10.1016/j.scitotenv.2017.06.151",
language = "English",
volume = "605-606",
pages = "1003--1010",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts. / Kim, Byung Mi; Chen, Mei Huei; Chen, Pau Chung; Park, Hyesook; Ha, Mina; Kim, Yangho; Hong, Yun-Chul; Kim, Young Ju; Ha, Eun Hee.

In: Science of the Total Environment, Vol. 605-606, 15.12.2017, p. 1003-1010.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts

AU - Kim, Byung Mi

AU - Chen, Mei Huei

AU - Chen, Pau Chung

AU - Park, Hyesook

AU - Ha, Mina

AU - Kim, Yangho

AU - Hong, Yun-Chul

AU - Kim, Young Ju

AU - Ha, Eun Hee

PY - 2017/12/15

Y1 - 2017/12/15

N2 - Prospective cohort studies of the effect of mercury (Hg) exposure on birth weight have shown conflicting results. We combined data from Taiwanese and Korean birth cohorts, and assessed the effects of Hg exposure on birth weight. The first cohort was drawn from the Mothers and Children's Environmental Health (MOCEH) study performed in Korea from 2006 to 2010. The second cohort was enrolled from 2004 to 2005 and included singleton term births from the Taiwan Birth Panel Study (TBPS). In total, 1147 pregnant women were included in this study. A pooled analysis was performed to obtain combined estimates of the association between prenatal total Hg exposure and birth weight. A significant negative association between maternal and cord blood Hg and birth weight in the high-Hg group (Hg level > 25th percentile) was detected (maternal blood: β = − 0.056; 95% CI, − 0.100 to − 0.013, cord blood: β = − 0.075; 95% CI, − 0.121 to − 0.028). Hg level showed a negative coefficient in the path analysis, indicating an adverse effect on birth weight (total effects: β = − 0.177, P = 0.01 in MOCEH, β = − 0.204, P = 0.03 in TBPS), but fish consumption exhibited a strong positive coefficient. In addition, fish consumption exerted a significant indirect effect on birth weight through exposure to cord blood Hg. Exposure to hazardous contaminants and beneficial nutrients may be highly correlated in those who frequently consume fish. Moreover, Hg in cord blood may adversely affect birth weight.

AB - Prospective cohort studies of the effect of mercury (Hg) exposure on birth weight have shown conflicting results. We combined data from Taiwanese and Korean birth cohorts, and assessed the effects of Hg exposure on birth weight. The first cohort was drawn from the Mothers and Children's Environmental Health (MOCEH) study performed in Korea from 2006 to 2010. The second cohort was enrolled from 2004 to 2005 and included singleton term births from the Taiwan Birth Panel Study (TBPS). In total, 1147 pregnant women were included in this study. A pooled analysis was performed to obtain combined estimates of the association between prenatal total Hg exposure and birth weight. A significant negative association between maternal and cord blood Hg and birth weight in the high-Hg group (Hg level > 25th percentile) was detected (maternal blood: β = − 0.056; 95% CI, − 0.100 to − 0.013, cord blood: β = − 0.075; 95% CI, − 0.121 to − 0.028). Hg level showed a negative coefficient in the path analysis, indicating an adverse effect on birth weight (total effects: β = − 0.177, P = 0.01 in MOCEH, β = − 0.204, P = 0.03 in TBPS), but fish consumption exhibited a strong positive coefficient. In addition, fish consumption exerted a significant indirect effect on birth weight through exposure to cord blood Hg. Exposure to hazardous contaminants and beneficial nutrients may be highly correlated in those who frequently consume fish. Moreover, Hg in cord blood may adversely affect birth weight.

KW - Birth weight

KW - Cohort

KW - Korea

KW - Mercury

KW - Prenatal exposure

KW - Taiwan

UR - http://www.scopus.com/inward/record.url?scp=85021744706&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2017.06.151

DO - 10.1016/j.scitotenv.2017.06.151

M3 - Article

VL - 605-606

SP - 1003

EP - 1010

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -