Paraneoplastic neuromyelitis optica associated with ANNA-1 antibodies in invasive thymoma

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Background: Thymoma is associated with various paraneoplastic autoimmune disorders. Herein, we report paraneoplastic neuromyelitis optica (NMO) associated with both anti-aquaporin-4 (AQP4) immunoglobulin G (IgG) and type 1 antineuronal nuclear antibody (ANNA-1) in an invasive thymoma patient.

Case presentation. A woman presented with a sudden onset of bilateral progressive visual loss associated with recurrence of invasive thymoma, 6 years after thymectomy and immunosuppressive treatment. AQP4-IgG and ANNA-1 were present in the patient's serum. Visual outcome was poor despite immunosuppressive treatment. Longitudinally extensive transverse myelitis developed 27 months after the onset of visual symptoms.

Conclusions: We have reported a case of paraneoplastic NMO associated with both AQP4-IgG and ANNA-1 autoantibodies in an invasive thymoma patient.

Original languageEnglish
Article number106
JournalBMC Ophthalmology
Issue number1
StatePublished - 3 Sep 2014


  • Antineuronal nuclear antibody
  • Paraneoplastic neuromyelitis optica
  • Thymoma

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