Outcome of multipair donor kidney exchange by a web-based algorithm

Beom Seok Kim, Yu Seun Kim, Soon Il Kim, Myoung Soo Kim, Ho Yung Lee, Yong Lim Kim, Chan Duck Kim, Chul Woo Yang, Bum Soon Choi, Duck Jong Han, Yon Su Kim, Sung Joo Kim, Ha Young Oh, Dae Joong Kim

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26 Scopus citations

Abstract

Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.

Original languageEnglish
Pages (from-to)1000-1006
Number of pages7
JournalJournal of the American Society of Nephrology
Volume18
Issue number3
DOIs
StatePublished - 1 Mar 2007

Cite this

Kim, B. S., Kim, Y. S., Kim, S. I., Kim, M. S., Lee, H. Y., Kim, Y. L., Kim, C. D., Yang, C. W., Choi, B. S., Han, D. J., Kim, Y. S., Kim, S. J., Oh, H. Y., & Kim, D. J. (2007). Outcome of multipair donor kidney exchange by a web-based algorithm. Journal of the American Society of Nephrology, 18(3), 1000-1006. https://doi.org/10.1681/ASN.2006101071