Abstract

IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.

Original languageEnglish
Pages (from-to)52-54
Number of pages3
JournalClinical and Experimental Otorhinolaryngology
Volume4
Issue number1
DOIs
StatePublished - 1 Mar 2011

Fingerprint

Immunoglobulins
Mixed Conductive-Sensorineural Hearing Loss
Hearing Disorders
Lacrimal Apparatus
Otitis Media with Effusion
Methylprednisolone
Prednisolone
Plasma Cells
Serum
Hearing Loss
Methotrexate
Pancreatitis
Autoimmune Diseases
Lymphocytes
Kidney
Recurrence
Lung

Keywords

  • Autoimmune disease
  • Hearing loss
  • Immunoglobulin G

Cite this

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title = "Otologic manifestation in IgG4-related systemic disease",
abstract = "IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.",
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Otologic manifestation in IgG4-related systemic disease. / Cho, Han Kyu; Lee, Yun-Jong; Chung, Jin-Haeng; Koo, Ja-Won.

In: Clinical and Experimental Otorhinolaryngology, Vol. 4, No. 1, 01.03.2011, p. 52-54.

Research output: Contribution to journalArticle

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AU - Lee, Yun-Jong

AU - Chung, Jin-Haeng

AU - Koo, Ja-Won

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AB - IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.

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