Organomimetic microsystems technologies

Jiheum Park, Kwang Bok Kim, Jungchul Lee, Hee Chan Kim, Dongeun Huh

Research output: Contribution to journalReview articleResearchpeer-review

10 Citations (Scopus)

Abstract

Microscale engineering technologies derived from the semiconductor and microelectronics industries provide new opportunities in biology to create and precisely control three-dimensional cell culture microenvironments in a physiologically relevant and organ-specific context. Here we review recent advances in the development of 'Organs-on-Chips' in which microsystems technologies have been applied to develop cell culture systems that recapitulate the structural, biochemical, and mechanical characteristics of living organs in order to mimic their complex physiology in vitro. We highlight these new capabilities and advantages enabled by microengineered tissue and organ mimics to show their potential as robust alternatives to conventional two- and three-dimensional cell culture systems, as well as a potential replacement for animal models. We also discuss how this biomimetic microengineering approach is beginning to meet challenges in drug development and environmental testing.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalBiomedical Engineering Letters
Volume2
Issue number2
DOIs
StatePublished - 1 Dec 2012

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Microsystems
Cell culture
Environmental testing
Engineering technology
Physiology
Biomimetics
Microelectronics
Animals
Tissue
Semiconductor materials
Industry

Keywords

  • Biomimetic microengineering
  • Cell culture systems
  • Microfluidics
  • Organs-on-Chips

Cite this

Park, Jiheum ; Kim, Kwang Bok ; Lee, Jungchul ; Kim, Hee Chan ; Huh, Dongeun. / Organomimetic microsystems technologies. In: Biomedical Engineering Letters. 2012 ; Vol. 2, No. 2. pp. 88-94.
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Organomimetic microsystems technologies. / Park, Jiheum; Kim, Kwang Bok; Lee, Jungchul; Kim, Hee Chan; Huh, Dongeun.

In: Biomedical Engineering Letters, Vol. 2, No. 2, 01.12.2012, p. 88-94.

Research output: Contribution to journalReview articleResearchpeer-review

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