On the society of genome: Social affiliation network analysis of microarray data

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

To investigate the structure of the genomic interaction network built from yeast gene-expression compendium dataset of hundreds of systematic perturbations, social affiliation network analysis methodologies were applied through quantifying various density, closeness and centrality measures and exploring core-periphery structures. Genes affected by a larger number of perturbations were found to be involved in responses to various environmental challenges. Deletion of essential genes was suggested to cause larger number of genes to be significantly up or down regulated. We explored the network structure made up of several sub-networks using core-periphery models to find ancient pathways. Glycolysis and TCA cycle have relatively core positions in the energy-related processes of yeast.

Original languageEnglish
Title of host publicationFuzzy Systems and Knowledge Discovery - Third International Conference, FSKD 2006, Proceedings
PublisherSpringer Verlag
Pages1062-1071
Number of pages10
ISBN (Print)3540459162, 9783540459163
DOIs
StatePublished - 2006
Event3rd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2006 - Xi'an, China
Duration: 24 Sep 200628 Sep 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4223 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other3rd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2006
Country/TerritoryChina
CityXi'an
Period24/09/0628/09/06

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