Obesity phenotype and incident hypertension

A prospective community-based cohort study

Seung Ku Lee, Seong Hwan Kim, Goo Yeong Cho, Inkyung Baik, Hong Euy Lim, Chang Gyu Park, Jung Bok Lee, Yong Hyun Kim, Sang Yup Lim, Hyun Kim, Chol Shin

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45 Citations (Scopus)

Abstract

Objective: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. Methods: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m), unhealthy overweight, healthy obesity (BMI 25 kg/m), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. Results: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort). Conclusion: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalJournal of Hypertension
Volume31
Issue number1
DOIs
StatePublished - 1 Jan 2013

Fingerprint

Cohort Studies
Obesity
Hypertension
Phenotype
Confidence Intervals
Weights and Measures
Incidence
Alcohol Drinking
Epidemiology
Cardiovascular Diseases
Smoking
Genome
Blood Pressure
Health

Keywords

  • epidemiology
  • hypertension
  • metabolic syndrome
  • obesity

Cite this

Lee, Seung Ku ; Kim, Seong Hwan ; Cho, Goo Yeong ; Baik, Inkyung ; Lim, Hong Euy ; Park, Chang Gyu ; Lee, Jung Bok ; Kim, Yong Hyun ; Lim, Sang Yup ; Kim, Hyun ; Shin, Chol. / Obesity phenotype and incident hypertension : A prospective community-based cohort study. In: Journal of Hypertension. 2013 ; Vol. 31, No. 1. pp. 145-151.
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title = "Obesity phenotype and incident hypertension: A prospective community-based cohort study",
abstract = "Objective: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. Methods: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m), unhealthy overweight, healthy obesity (BMI 25 kg/m), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. Results: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95{\%} confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95{\%} CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95{\%} CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95{\%} CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95{\%} CI 1.01-4.83 for the Ansung cohort). Conclusion: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.",
keywords = "epidemiology, hypertension, metabolic syndrome, obesity",
author = "Lee, {Seung Ku} and Kim, {Seong Hwan} and Cho, {Goo Yeong} and Inkyung Baik and Lim, {Hong Euy} and Park, {Chang Gyu} and Lee, {Jung Bok} and Kim, {Yong Hyun} and Lim, {Sang Yup} and Hyun Kim and Chol Shin",
year = "2013",
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Lee, SK, Kim, SH, Cho, GY, Baik, I, Lim, HE, Park, CG, Lee, JB, Kim, YH, Lim, SY, Kim, H & Shin, C 2013, 'Obesity phenotype and incident hypertension: A prospective community-based cohort study', Journal of Hypertension, vol. 31, no. 1, pp. 145-151. https://doi.org/10.1097/HJH.0b013e32835a3637

Obesity phenotype and incident hypertension : A prospective community-based cohort study. / Lee, Seung Ku; Kim, Seong Hwan; Cho, Goo Yeong; Baik, Inkyung; Lim, Hong Euy; Park, Chang Gyu; Lee, Jung Bok; Kim, Yong Hyun; Lim, Sang Yup; Kim, Hyun; Shin, Chol.

In: Journal of Hypertension, Vol. 31, No. 1, 01.01.2013, p. 145-151.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Obesity phenotype and incident hypertension

T2 - A prospective community-based cohort study

AU - Lee, Seung Ku

AU - Kim, Seong Hwan

AU - Cho, Goo Yeong

AU - Baik, Inkyung

AU - Lim, Hong Euy

AU - Park, Chang Gyu

AU - Lee, Jung Bok

AU - Kim, Yong Hyun

AU - Lim, Sang Yup

AU - Kim, Hyun

AU - Shin, Chol

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. Methods: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m), unhealthy overweight, healthy obesity (BMI 25 kg/m), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. Results: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort). Conclusion: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.

AB - Objective: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. Methods: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m), unhealthy overweight, healthy obesity (BMI 25 kg/m), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. Results: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort). Conclusion: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.

KW - epidemiology

KW - hypertension

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