Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity. Aim: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. Methods: Subjects who received health screening, including mammography and breast and hepatic ultrasonography simultaneously, were included. Subjects diagnosed with breast cancer were matched with controls. Conditional logistic regression analyses were performed. Results: Among 270 breast cancer patients and 270 controls, 81 cancer patients (30.0%) and 54 controls (20.0%) had NAFLD (P = 0.008). NAFLD was significantly associated with breast cancer in multivariate analysis (P = 0.046). When the interaction between obesity (BMI < 25 kg/m2 vs. ≥25 kg/m2) and NAFLD in breast cancer patients was examined, a significant effect modification between obesity and NAFLD in breast cancer was noted (P = 0.021). The subgroup analysis showed that NAFLD was significantly associated with breast cancer in the nonobese subgroup (odds ratio 3.04, 95% confidence interval 1.37–4.32, P = 0.002) but not in the obese group (P = 0.163). Conclusions: NAFLD was significantly associated with breast cancer independent of traditional risk factors, and this association existed in the nonobese subgroup but not in the obese subgroup.

Original languageEnglish
Pages (from-to)1030-1035
Number of pages6
JournalDigestive and Liver Disease
Volume51
Issue number7
DOIs
StatePublished - 1 Jul 2019

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Breast Neoplasms
Obesity
Liver Neoplasms
Mammary Ultrasonography
Non-alcoholic Fatty Liver Disease
Mammography
Case-Control Studies
Neoplasms
Multivariate Analysis
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Liver
Health

Keywords

  • Breast cancer
  • Fatty liver
  • Hepatic steatosis
  • Obesity

Cite this

@article{b0ead64deb4441f090dc5573e1721d12,
title = "Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women",
abstract = "Background: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity. Aim: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. Methods: Subjects who received health screening, including mammography and breast and hepatic ultrasonography simultaneously, were included. Subjects diagnosed with breast cancer were matched with controls. Conditional logistic regression analyses were performed. Results: Among 270 breast cancer patients and 270 controls, 81 cancer patients (30.0{\%}) and 54 controls (20.0{\%}) had NAFLD (P = 0.008). NAFLD was significantly associated with breast cancer in multivariate analysis (P = 0.046). When the interaction between obesity (BMI < 25 kg/m2 vs. ≥25 kg/m2) and NAFLD in breast cancer patients was examined, a significant effect modification between obesity and NAFLD in breast cancer was noted (P = 0.021). The subgroup analysis showed that NAFLD was significantly associated with breast cancer in the nonobese subgroup (odds ratio 3.04, 95{\%} confidence interval 1.37–4.32, P = 0.002) but not in the obese group (P = 0.163). Conclusions: NAFLD was significantly associated with breast cancer independent of traditional risk factors, and this association existed in the nonobese subgroup but not in the obese subgroup.",
keywords = "Breast cancer, Fatty liver, Hepatic steatosis, Obesity",
author = "Kwak, {Min Sun} and Yim, {Jeong Yoon} and Ann Yi and Chung, {Goh Eun} and Yang, {Jong In} and Donghee Kim and Joo-Sung Kim and Dongyoung Noh",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.dld.2018.12.024",
language = "English",
volume = "51",
pages = "1030--1035",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier",
number = "7",

}

Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women. / Kwak, Min Sun; Yim, Jeong Yoon; Yi, Ann; Chung, Goh Eun; Yang, Jong In; Kim, Donghee; Kim, Joo-Sung; Noh, Dongyoung.

In: Digestive and Liver Disease, Vol. 51, No. 7, 01.07.2019, p. 1030-1035.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women

AU - Kwak, Min Sun

AU - Yim, Jeong Yoon

AU - Yi, Ann

AU - Chung, Goh Eun

AU - Yang, Jong In

AU - Kim, Donghee

AU - Kim, Joo-Sung

AU - Noh, Dongyoung

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity. Aim: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. Methods: Subjects who received health screening, including mammography and breast and hepatic ultrasonography simultaneously, were included. Subjects diagnosed with breast cancer were matched with controls. Conditional logistic regression analyses were performed. Results: Among 270 breast cancer patients and 270 controls, 81 cancer patients (30.0%) and 54 controls (20.0%) had NAFLD (P = 0.008). NAFLD was significantly associated with breast cancer in multivariate analysis (P = 0.046). When the interaction between obesity (BMI < 25 kg/m2 vs. ≥25 kg/m2) and NAFLD in breast cancer patients was examined, a significant effect modification between obesity and NAFLD in breast cancer was noted (P = 0.021). The subgroup analysis showed that NAFLD was significantly associated with breast cancer in the nonobese subgroup (odds ratio 3.04, 95% confidence interval 1.37–4.32, P = 0.002) but not in the obese group (P = 0.163). Conclusions: NAFLD was significantly associated with breast cancer independent of traditional risk factors, and this association existed in the nonobese subgroup but not in the obese subgroup.

AB - Background: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity. Aim: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. Methods: Subjects who received health screening, including mammography and breast and hepatic ultrasonography simultaneously, were included. Subjects diagnosed with breast cancer were matched with controls. Conditional logistic regression analyses were performed. Results: Among 270 breast cancer patients and 270 controls, 81 cancer patients (30.0%) and 54 controls (20.0%) had NAFLD (P = 0.008). NAFLD was significantly associated with breast cancer in multivariate analysis (P = 0.046). When the interaction between obesity (BMI < 25 kg/m2 vs. ≥25 kg/m2) and NAFLD in breast cancer patients was examined, a significant effect modification between obesity and NAFLD in breast cancer was noted (P = 0.021). The subgroup analysis showed that NAFLD was significantly associated with breast cancer in the nonobese subgroup (odds ratio 3.04, 95% confidence interval 1.37–4.32, P = 0.002) but not in the obese group (P = 0.163). Conclusions: NAFLD was significantly associated with breast cancer independent of traditional risk factors, and this association existed in the nonobese subgroup but not in the obese subgroup.

KW - Breast cancer

KW - Fatty liver

KW - Hepatic steatosis

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85060336514&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2018.12.024

DO - 10.1016/j.dld.2018.12.024

M3 - Article

VL - 51

SP - 1030

EP - 1035

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 7

ER -