Non-obese fatty liver disease is associated with lacunar infarct

Min Sun Kwak, Kyung Won Kim, Hyobin Seo, Goh Eun Chung, Jeong Yoon Yim, Donghee Kim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background/Aims: Lacunar infarct, a small subcortical ischaemic lesion, is a known risk factor for future cognitive impairment, dementia and stroke. We evaluated the relationship between fatty liver disease (FLD) and lacunar infarct in a healthy general population. Methods: Subjects who underwent brain magnetic resonance imaging (MRI) and abdominal ultrasonography (US) during health check-ups from 2007 to 2009 were included. FLD was diagnosed by US. Subjects with a history of cerebrovascular disease, radiological findings consistent with cerebrovascular stenosis or cerebral small vessel disease were excluded. Results: Of the 1277 subjects, 54 (4.2%) exhibited lacunar infarct, and 514 (40.3%) had FLD. Subjects with lacunar infarct had a higher prevalence of FLD (59.3% vs 39.4%, P =.004). There was significant interaction between obesity (BMI < 25 kg/m 2 vs ≥ 25 kg/m 2 ) and FLD for lacunar infarct (P for interaction =.024). Subgroup analysis revealed that non-obese FLD was more common in the subjects with lacunar infarct than those without (51.7% vs 23.5%, P =.001). However, there was no significant difference in the obese FLD prevalence between these 2 groups. In multivariate models adjusted by age, sex, smoking, alcohol, hypertension and diabetes, FLD was significantly associated with lacunar infarct (odds ratio [OR] 1.97; 95% confidence interval [CI] 1.08-3.58; P =.027). Non-obese FLD was associated with lacunar infarct (OR 3.58; 95% CI 1.63-7.89; P =.002); however, this association remained insignificant in obese FLD. Instead, ageing and hypertension were independent risk factors for lacunar infarct in the obese population. Conclusions: FLD is significantly associated with lacunar infarct, independent of traditional risk factors. This association was prominent in the non-obese population.

Original languageEnglish
Pages (from-to)1292-1299
Number of pages8
JournalLiver International
Issue number7
StatePublished - Jul 2018


  • atherosclerosis
  • cerebral infarct
  • hepatic steatosis
  • lacunar infarct

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