Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Kum Ju Chae, Hyunsook Hong, Soon Ho Yoon, Seokyung Hahn, Gong Yong Jin, Chang Min Park, Jin Mo Goo

Research output: Contribution to journalArticle

Abstract

Non-diagnostic results can affect the diagnostic performance of percutaneous transthoracic needle biopsy (PTNB) but have not been critically meta-analyzed yet. To meta-analyze the incidence and malignancy rate of non-diagnostic results, 3-by-2 table approaches rather than the conventional 2-by-2 approaches are needed to know its impact on the diagnostic performance of PTNB. A systematic literature search identified studies evaluating the diagnostic performance of PTNB with extractable outcomes. A total of 143 studies with 35,059 biopsies were included. The pooled incidence of non-diagnostic results was 6.8% (95% CI, 6.0–7.6%; I2 = 0.91). The pooled malignancy rate of non-diagnostic results was 59.3% (95% CI, 51.7–66.8%; I2 = 0.80), and was correlated with the prevalence of malignancy (correlation coefficient, 0.66; 95% CI, 0.42–0.91). Pooled percentage decrease of sensitivity and specificity due to non-diagnostic results were 4.5% (95% CI, 3.2–5.7%; I2 = 0.64) and 10.7% (95% CI, 7.7–13.7%; I2 = 0.70), respectively, and the pooled incidence of non-diagnostic results was 4.4% (95% CI, 3.2–5.8%; I2 = 0.83) in lesions ultimately diagnosed as malignancies and 10.4% (95% CI, 7.5–13.8%; I2 = 0.74) in benign disease. In conclusion, non-diagnostic results averagely occurred in 6.8% of PTNB and more than half of the results were malignancies. The non-diagnostic results decreased specificity and sensitivity by 10.7% and 4.5%, respectively, demanding efforts to minimize the non-diagnostic results in PTNB.

Original languageEnglish
Article number12428
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Needle Biopsy
Meta-Analysis
Neoplasms
Incidence
Sensitivity and Specificity
Biopsy

Cite this

@article{36ebf205a9c547418f94228aea285868,
title = "Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy: A Meta-analysis",
abstract = "Non-diagnostic results can affect the diagnostic performance of percutaneous transthoracic needle biopsy (PTNB) but have not been critically meta-analyzed yet. To meta-analyze the incidence and malignancy rate of non-diagnostic results, 3-by-2 table approaches rather than the conventional 2-by-2 approaches are needed to know its impact on the diagnostic performance of PTNB. A systematic literature search identified studies evaluating the diagnostic performance of PTNB with extractable outcomes. A total of 143 studies with 35,059 biopsies were included. The pooled incidence of non-diagnostic results was 6.8{\%} (95{\%} CI, 6.0–7.6{\%}; I2 = 0.91). The pooled malignancy rate of non-diagnostic results was 59.3{\%} (95{\%} CI, 51.7–66.8{\%}; I2 = 0.80), and was correlated with the prevalence of malignancy (correlation coefficient, 0.66; 95{\%} CI, 0.42–0.91). Pooled percentage decrease of sensitivity and specificity due to non-diagnostic results were 4.5{\%} (95{\%} CI, 3.2–5.7{\%}; I2 = 0.64) and 10.7{\%} (95{\%} CI, 7.7–13.7{\%}; I2 = 0.70), respectively, and the pooled incidence of non-diagnostic results was 4.4{\%} (95{\%} CI, 3.2–5.8{\%}; I2 = 0.83) in lesions ultimately diagnosed as malignancies and 10.4{\%} (95{\%} CI, 7.5–13.8{\%}; I2 = 0.74) in benign disease. In conclusion, non-diagnostic results averagely occurred in 6.8{\%} of PTNB and more than half of the results were malignancies. The non-diagnostic results decreased specificity and sensitivity by 10.7{\%} and 4.5{\%}, respectively, demanding efforts to minimize the non-diagnostic results in PTNB.",
author = "Chae, {Kum Ju} and Hyunsook Hong and Yoon, {Soon Ho} and Seokyung Hahn and Jin, {Gong Yong} and Park, {Chang Min} and Goo, {Jin Mo}",
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Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy : A Meta-analysis. / Chae, Kum Ju; Hong, Hyunsook; Yoon, Soon Ho; Hahn, Seokyung; Jin, Gong Yong; Park, Chang Min; Goo, Jin Mo.

In: Scientific Reports, Vol. 9, No. 1, 12428, 01.12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy

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AU - Chae, Kum Ju

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AB - Non-diagnostic results can affect the diagnostic performance of percutaneous transthoracic needle biopsy (PTNB) but have not been critically meta-analyzed yet. To meta-analyze the incidence and malignancy rate of non-diagnostic results, 3-by-2 table approaches rather than the conventional 2-by-2 approaches are needed to know its impact on the diagnostic performance of PTNB. A systematic literature search identified studies evaluating the diagnostic performance of PTNB with extractable outcomes. A total of 143 studies with 35,059 biopsies were included. The pooled incidence of non-diagnostic results was 6.8% (95% CI, 6.0–7.6%; I2 = 0.91). The pooled malignancy rate of non-diagnostic results was 59.3% (95% CI, 51.7–66.8%; I2 = 0.80), and was correlated with the prevalence of malignancy (correlation coefficient, 0.66; 95% CI, 0.42–0.91). Pooled percentage decrease of sensitivity and specificity due to non-diagnostic results were 4.5% (95% CI, 3.2–5.7%; I2 = 0.64) and 10.7% (95% CI, 7.7–13.7%; I2 = 0.70), respectively, and the pooled incidence of non-diagnostic results was 4.4% (95% CI, 3.2–5.8%; I2 = 0.83) in lesions ultimately diagnosed as malignancies and 10.4% (95% CI, 7.5–13.8%; I2 = 0.74) in benign disease. In conclusion, non-diagnostic results averagely occurred in 6.8% of PTNB and more than half of the results were malignancies. The non-diagnostic results decreased specificity and sensitivity by 10.7% and 4.5%, respectively, demanding efforts to minimize the non-diagnostic results in PTNB.

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