New breast cancer risk variant discovered at 10q25 in East Asian women

Jiajun Shi, Hyuna Sung, Ben Zhang, Wei Lu, Ji Yeob Choi, Yong Bing Xiang, Mi Kyung Kim, Motoki Iwasaki, Jirong Long, Bu Tian Ji, Sue K. Park, Ying Zheng, Shoichiro Tsugane, Keun Young Yoo, Wenjing Wang, Dong Young Noh, Wonshik Han, Sung Won Kim, Min Hyuk Lee, Jong Won LeeJong Young Lee, Chen Yang Shen, Keitaro Matsuo, Sei Hyun Ahn, Yu Tang Gao, Xiao Ou Shu, Qiuyin Cai, Daehee Kang, Wei Zheng

Research output: Contribution to journalArticle

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Abstract

Background: Recently, 41 new genetic susceptibility loci for breast cancer risk were identified in a genome-wide association study (GWAS) conducted in European descendants. Most of these risk variants have not been directly replicated in Asian populations. Methods: We evaluated nine of those nonreplication loci in East Asians to identify new risk variants for breast cancer in these regions. First, we analyzed single-nucleotide polymorphisms (SNP) in these regions using data from two GWAS conducted among Chinese and Korean women, including 5,083 cases and 4,376 controls (stage 1). In each region, we selected an SNP showing the strongest association with breast cancer risk for replication in an independent set of 7,294 cases and 9,404 controls of East Asian descents (stage 2). Logistic regression models were used to calculate adjusted ORs and 95% confidence intervals (CI) as a measure of the association of breast cancer risk and genetic variants. Results: Two SNPs were replicated in stage 2 at P < 0.05: rs1419026 at 6q14 [per allele OR, 1.07; 95% confidence interval (CI), 1.03-1.12; P = 3.0 × 10-4] and rs941827 at 10q25 (OR, 0.92, 95% CI, 0.89-0.96; P = 5.3 × 10-8). The association with rs941827 remained highly statistically significant after adjusting for the risk variant identified initially in women of European ancestry (OR, 0.88; 95% CI, 0.82-0.97; P = 5.3 × 10-5). Conclusion: We identified a new breast cancer risk variant at 10q25 in East Asian women. Impact: Results from this study improve the understanding of the genetic basis for breast cancer.

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number7
DOIs
StatePublished - Jul 2013

Cite this

Shi, J., Sung, H., Zhang, B., Lu, W., Choi, J. Y., Xiang, Y. B., Kim, M. K., Iwasaki, M., Long, J., Ji, B. T., Park, S. K., Zheng, Y., Tsugane, S., Yoo, K. Y., Wang, W., Noh, D. Y., Han, W., Kim, S. W., Lee, M. H., ... Zheng, W. (2013). New breast cancer risk variant discovered at 10q25 in East Asian women. Cancer Epidemiology Biomarkers and Prevention, 22(7), 1297-1303. https://doi.org/10.1158/1055-9965.EPI-12-1393