Neuroprotective effect of Ginkgo biloba L. extract in a rat model of parkinson's disease

M. S. Kim, J. I. Lee, W. Y. Lee, Sang Eun Kim

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The neuroprotective effects of a standardized extract of Ginkgo biloba L. (EGb 761) were investigated on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in the nigrostriatal dopaminergic system of the rat brain. Rats were given a week of pretreatment with daily administrations of EGb 761. Unilateral striatal injection of 6-OHDA was followed by treatment with EGb 761 for a week. Serial measurement of contralateral forepaw adjusting steps revealed a progressive deficit in motor activity. At 8 weeks after 6-OHDA lesion the number of contralateral forepaw adjusting steps was significantly higher in rats that were treated with high doses of EGb 761 (100 mg/kg daily) than in those treated with low doses (50 mg/kg) or with the vehicle. Dopamine neuron loss in the substantia nigra and a depletion in striatal dopamine corresponded with behavioural deficit. These data suggest that the neuroprotective effects of EGb 761 reduce the behavioural deficit in 6-OHDA lesions in rat and also indicates a possible role for the extract in the treatment of Parkinson's disease.

Original languageEnglish
Pages (from-to)663-666
Number of pages4
JournalPhytotherapy Research
Volume18
Issue number8
DOIs
StatePublished - 1 Aug 2004

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Ginkgo biloba
Oxidopamine
Neuroprotective Agents
Parkinson Disease
Corpus Striatum
Dopaminergic Neurons
Substantia Nigra
Dopamine
Motor Activity
Ginkgo biloba extract 761
Injections
Brain
Therapeutics

Keywords

  • 6-hydroxydopamine
  • Ginkgo biloba extract
  • Parkinson's disease

Cite this

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Neuroprotective effect of Ginkgo biloba L. extract in a rat model of parkinson's disease. / Kim, M. S.; Lee, J. I.; Lee, W. Y.; Kim, Sang Eun.

In: Phytotherapy Research, Vol. 18, No. 8, 01.08.2004, p. 663-666.

Research output: Contribution to journalArticle

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