Nationwide seroepidemiology of hepatitis B virus infection in South Korea in 2009 emphasizes the coexistence of HBsAg and anti-HBs

Byung Seok Lee, Yong Kyun Cho, Sook Hyang Jeong, Joon Hyeok Lee, Don Lee, Neung Hwa Park, Moran Ki

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated the seroprevalence of HBV infection with an emphasis on the coexistence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In all, 290,212 people undergoing health check-up examinations in 29 institutions during 2009 were recruited. The crude seroprevalences of HBsAg and anti-HBs was adjusted by age, sex, and geographic area using the 2009 estimated population of Korea. The adjusted seroprevalences of HBsAg and anti-HBs was 4.0% and 73.5%, respectively. Males showed higher HBsAg positivity and lower anti-HBs positivity than females (P<0.001). HBsAg positivity increased with age from 3.5% in people 20-29 years old to 4.8% in people 40-49 years old, followed by a decrease in people ≥50 years old. HBsAg positivity in Southern provinces (4.5%) including Jeju (5.9%), was significantly higher than that in Central provinces (3.6%; P<0.001). Interestingly, HBsAg and anti-HBs coexisted in 0.1% of the total subjects and in 2.9% of the HBsAg-positive group, showing distinct age distribution and higher alanine aminotransferase levels than those of the group positive for only HBsAg. In conclusion, the seroprevalence of HBsAg and anti-HBs in Korea varies significantly by age, sex and geographical location and coexisted in 2.9% of HBsAg-positive subjects. Continuous monitoring of seroepidemiology may facilitate the eventual eradication of HBV infection.

Original languageEnglish
Pages (from-to)1327-1333
Number of pages7
JournalJournal of Medical Virology
Volume85
Issue number8
DOIs
StatePublished - 1 Aug 2013

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Republic of Korea
Virus Diseases
Hepatitis B Surface Antigens
Hepatitis B virus
Seroepidemiologic Studies
Korea
Hepatitis B Antibodies
Age Distribution
Alanine Transaminase
Liver Diseases
Chronic Disease

Keywords

  • Epidemiology
  • Hepatitis B virus
  • Korea
  • Seroprevalence
  • Vaccination

Cite this

Lee, Byung Seok ; Cho, Yong Kyun ; Jeong, Sook Hyang ; Lee, Joon Hyeok ; Lee, Don ; Park, Neung Hwa ; Ki, Moran. / Nationwide seroepidemiology of hepatitis B virus infection in South Korea in 2009 emphasizes the coexistence of HBsAg and anti-HBs. In: Journal of Medical Virology. 2013 ; Vol. 85, No. 8. pp. 1327-1333.
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title = "Nationwide seroepidemiology of hepatitis B virus infection in South Korea in 2009 emphasizes the coexistence of HBsAg and anti-HBs",
abstract = "Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated the seroprevalence of HBV infection with an emphasis on the coexistence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In all, 290,212 people undergoing health check-up examinations in 29 institutions during 2009 were recruited. The crude seroprevalences of HBsAg and anti-HBs was adjusted by age, sex, and geographic area using the 2009 estimated population of Korea. The adjusted seroprevalences of HBsAg and anti-HBs was 4.0{\%} and 73.5{\%}, respectively. Males showed higher HBsAg positivity and lower anti-HBs positivity than females (P<0.001). HBsAg positivity increased with age from 3.5{\%} in people 20-29 years old to 4.8{\%} in people 40-49 years old, followed by a decrease in people ≥50 years old. HBsAg positivity in Southern provinces (4.5{\%}) including Jeju (5.9{\%}), was significantly higher than that in Central provinces (3.6{\%}; P<0.001). Interestingly, HBsAg and anti-HBs coexisted in 0.1{\%} of the total subjects and in 2.9{\%} of the HBsAg-positive group, showing distinct age distribution and higher alanine aminotransferase levels than those of the group positive for only HBsAg. In conclusion, the seroprevalence of HBsAg and anti-HBs in Korea varies significantly by age, sex and geographical location and coexisted in 2.9{\%} of HBsAg-positive subjects. Continuous monitoring of seroepidemiology may facilitate the eventual eradication of HBV infection.",
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Nationwide seroepidemiology of hepatitis B virus infection in South Korea in 2009 emphasizes the coexistence of HBsAg and anti-HBs. / Lee, Byung Seok; Cho, Yong Kyun; Jeong, Sook Hyang; Lee, Joon Hyeok; Lee, Don; Park, Neung Hwa; Ki, Moran.

In: Journal of Medical Virology, Vol. 85, No. 8, 01.08.2013, p. 1327-1333.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lee, Byung Seok

AU - Cho, Yong Kyun

AU - Jeong, Sook Hyang

AU - Lee, Joon Hyeok

AU - Lee, Don

AU - Park, Neung Hwa

AU - Ki, Moran

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AB - Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated the seroprevalence of HBV infection with an emphasis on the coexistence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In all, 290,212 people undergoing health check-up examinations in 29 institutions during 2009 were recruited. The crude seroprevalences of HBsAg and anti-HBs was adjusted by age, sex, and geographic area using the 2009 estimated population of Korea. The adjusted seroprevalences of HBsAg and anti-HBs was 4.0% and 73.5%, respectively. Males showed higher HBsAg positivity and lower anti-HBs positivity than females (P<0.001). HBsAg positivity increased with age from 3.5% in people 20-29 years old to 4.8% in people 40-49 years old, followed by a decrease in people ≥50 years old. HBsAg positivity in Southern provinces (4.5%) including Jeju (5.9%), was significantly higher than that in Central provinces (3.6%; P<0.001). Interestingly, HBsAg and anti-HBs coexisted in 0.1% of the total subjects and in 2.9% of the HBsAg-positive group, showing distinct age distribution and higher alanine aminotransferase levels than those of the group positive for only HBsAg. In conclusion, the seroprevalence of HBsAg and anti-HBs in Korea varies significantly by age, sex and geographical location and coexisted in 2.9% of HBsAg-positive subjects. Continuous monitoring of seroepidemiology may facilitate the eventual eradication of HBV infection.

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