Myriocin, a serine palmitoyltransferase inhibitor, increases melanin synthesis in Mel-Ab cells and a skin equivalent model

Hailan Li, Hye Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Kyoung Chan Park, Dong Seok Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to investigate effects of myriocin, an inhibitor of serine palmitoyltransferase, on melanogenesis. It was found that myriocin increased melanin synthesis in a concentration-dependent manner. Moreover, myriocin up-regulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression via phosphorylation of CREB, but it did not directly activate tyrosinase, a rate-limiting melanogenic enzyme. Furthermore, we demonstrated increased melanin synthesis with myriocin on a pigmented skin equivalent model established using Cervi cornus Colla (deer antler glue). One and 5 μM of myriocin darkened the color of the skin equivalent. These results suggest that myriocin may have potential effects for the treatment of hypopigmentary skin diseases like vitiligo or for sunless tanning.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalPharmazie
Volume69
Issue number3
DOIs
StatePublished - Mar 2014

Fingerprint

Serine C-Palmitoyltransferase
Melanins
Skin
Monophenol Monooxygenase
Cornus
Antlers
Microphthalmia-Associated Transcription Factor
Tanning
Skin Pigmentation
Vitiligo
Deer
Skin Diseases
Adhesives
thermozymocidin
Phosphorylation
Enzymes

Cite this

Li, Hailan ; Yun, Hye Young ; Baek, Kwang Jin ; Kwon, Nyoun Soo ; Park, Kyoung Chan ; Kim, Dong Seok. / Myriocin, a serine palmitoyltransferase inhibitor, increases melanin synthesis in Mel-Ab cells and a skin equivalent model. In: Pharmazie. 2014 ; Vol. 69, No. 3. pp. 187-191.
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abstract = "The purpose of this study was to investigate effects of myriocin, an inhibitor of serine palmitoyltransferase, on melanogenesis. It was found that myriocin increased melanin synthesis in a concentration-dependent manner. Moreover, myriocin up-regulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression via phosphorylation of CREB, but it did not directly activate tyrosinase, a rate-limiting melanogenic enzyme. Furthermore, we demonstrated increased melanin synthesis with myriocin on a pigmented skin equivalent model established using Cervi cornus Colla (deer antler glue). One and 5 μM of myriocin darkened the color of the skin equivalent. These results suggest that myriocin may have potential effects for the treatment of hypopigmentary skin diseases like vitiligo or for sunless tanning.",
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Myriocin, a serine palmitoyltransferase inhibitor, increases melanin synthesis in Mel-Ab cells and a skin equivalent model. / Li, Hailan; Yun, Hye Young; Baek, Kwang Jin; Kwon, Nyoun Soo; Park, Kyoung Chan; Kim, Dong Seok.

In: Pharmazie, Vol. 69, No. 3, 03.2014, p. 187-191.

Research output: Contribution to journalArticle

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AU - Li, Hailan

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AU - Park, Kyoung Chan

AU - Kim, Dong Seok

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AB - The purpose of this study was to investigate effects of myriocin, an inhibitor of serine palmitoyltransferase, on melanogenesis. It was found that myriocin increased melanin synthesis in a concentration-dependent manner. Moreover, myriocin up-regulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression via phosphorylation of CREB, but it did not directly activate tyrosinase, a rate-limiting melanogenic enzyme. Furthermore, we demonstrated increased melanin synthesis with myriocin on a pigmented skin equivalent model established using Cervi cornus Colla (deer antler glue). One and 5 μM of myriocin darkened the color of the skin equivalent. These results suggest that myriocin may have potential effects for the treatment of hypopigmentary skin diseases like vitiligo or for sunless tanning.

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