Myocardial positron emission tomography for evaluation of cardiac sarcoidosis: Specialized protocols for better diagnosis

In Chang Hwang, Ji In Bang, Yeonyee E. Yoon, Won Woo Lee

Research output: Contribution to journalReview article

Abstract

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology with various clinical presentations depending on the organs involved. Since cardiac sarcoidosis (CS) portends a higher risk of morbidity and mortality, early diagnosis and aggressive medical treatment are essential to improve the prognosis.18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as an important tool with practical advantages in assessing disease activity and monitoring the treatment response in patients with CS. While it has high sensitivity, it also has great variability in specificity, probably due to normal physiologic myocardial FDG uptake, which interferes with the evaluation and follow-up of CS using FDG-PET. This review details the technical aspects of FDG-PET imaging for evaluating and diagnosing CS, assessing disease activity, and monitoring therapeutic response.

Original languageEnglish
Article numbere24
JournalJournal of Cardiovascular Imaging
Volume28
Issue number1
DOIs
StatePublished - 1 Jan 2019

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Keywords

  • Cardiac sarcoidosis
  • Extended fasting
  • High-fat low-carbohydrate diet
  • Multimodality imaging
  • Myocardial positron emission tomography

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