Morphometry of the trochlear nerve and superior oblique muscle volume in congenital superior oblique palsy

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Abstract

PURPOSE. To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients \with congenital SOP.

RESULTS. Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n=87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n=38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P=0.001), and larger than controls in the present group (P=0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P=0.014, R2=0.174) and in the nonparetic sides of congenital SOP (present group P=0.023, R2=0.135; absent group, P=0.008, R2=0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P=0.243).

METHODS. The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section highresolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship.

CONCLUSIONS. In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP.

Original languageEnglish
Pages (from-to)8571-8575
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number12
DOIs
StatePublished - 7 Nov 2014

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Oculomotor Muscles
Trochlear Nerve
Paralysis
Trochlear Nerve Diseases
Medical Records
Magnetic Resonance Imaging

Keywords

  • Congenital superior oblique palsy
  • Superior oblique muscle
  • Trochlear nerve

Cite this

@article{8fb10887fe2a4f199c79a3e91425be93,
title = "Morphometry of the trochlear nerve and superior oblique muscle volume in congenital superior oblique palsy",
abstract = "PURPOSE. To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients \with congenital SOP.RESULTS. Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n=87, 70{\%}, absent group) and 38 showed bilateral presence of the trochlear nerve (n=38, 30{\%}, present group). The nonparetic side CN4D was smaller than controls in the absent group (P=0.001), and larger than controls in the present group (P=0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P=0.014, R2=0.174) and in the nonparetic sides of congenital SOP (present group P=0.023, R2=0.135; absent group, P=0.008, R2=0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P=0.243).METHODS. The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section highresolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship.CONCLUSIONS. In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP.",
keywords = "Congenital superior oblique palsy, Superior oblique muscle, Trochlear nerve",
author = "Lee, {Dae Seung} and Yang, {Hee Kyung} and Kim, {Jae Hyoung} and Jeong-Min Hwang",
year = "2014",
month = "11",
day = "7",
doi = "10.1167/iovs.14-15323",
language = "English",
volume = "55",
pages = "8571--8575",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "12",

}

TY - JOUR

T1 - Morphometry of the trochlear nerve and superior oblique muscle volume in congenital superior oblique palsy

AU - Lee, Dae Seung

AU - Yang, Hee Kyung

AU - Kim, Jae Hyoung

AU - Hwang, Jeong-Min

PY - 2014/11/7

Y1 - 2014/11/7

N2 - PURPOSE. To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients \with congenital SOP.RESULTS. Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n=87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n=38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P=0.001), and larger than controls in the present group (P=0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P=0.014, R2=0.174) and in the nonparetic sides of congenital SOP (present group P=0.023, R2=0.135; absent group, P=0.008, R2=0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P=0.243).METHODS. The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section highresolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship.CONCLUSIONS. In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP.

AB - PURPOSE. To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients \with congenital SOP.RESULTS. Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n=87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n=38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P=0.001), and larger than controls in the present group (P=0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P=0.014, R2=0.174) and in the nonparetic sides of congenital SOP (present group P=0.023, R2=0.135; absent group, P=0.008, R2=0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P=0.243).METHODS. The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section highresolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship.CONCLUSIONS. In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP.

KW - Congenital superior oblique palsy

KW - Superior oblique muscle

KW - Trochlear nerve

UR - http://www.scopus.com/inward/record.url?scp=84920105100&partnerID=8YFLogxK

U2 - 10.1167/iovs.14-15323

DO - 10.1167/iovs.14-15323

M3 - Article

C2 - 25414184

AN - SCOPUS:84920105100

VL - 55

SP - 8571

EP - 8575

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 12

ER -