Monte Carlo study for pinhole X-ray fluorescence imaging of gadolinium nanoparticles

Seongmoon Jung, Wonmo Sung, Sung-Joon Ye

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

This work aims to develop a Monte Carlo (MC) model of pinhole x-ray fluorescence imaging for gadolinium nanoparticles (GdNPs) in a cylindrical water phantom and to derive the relationship between imaging dose and quality for different x-ray spectra. We constructed four Gd columns in the water phantom which had different concentrations: 0.01%, 0.03%, 0.06%, and 0.09% by weight of Gd The water phantom with and without Gd columns were irradiated by fan beams of 51 keV and 60 keV monochromatic x-rays. The spectrum of 110 kVp polychromatic x-rays with 3-mm-thick Be and 2-mm-thick Al filter was extracted from SpekCalc code. 110 kVp x-rays with 3-mm-thick Be and 0.3-mm-thick W filter were also used to irradiate the phantoms. The images were evaluated by Contrast to Noise Ratio (CNR). The imaging dose to water of each x-ray source was also calculated by MC simulations. Finally, we could estimate the dose required to achieve CNR=3. The spectrum of 110 kVp x-ray with 3-mm-thick Be and 0.3-mm-thick Wfilter was shown to be the best incident x-ray in terms of reducing dose while achieve high quality image. The MC simulations demonstrated the feasibility of pinhole x-ray fluorescence imaging of Gd nanoparticles.

Original languageEnglish
Title of host publication2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781467398626
DOIs
StatePublished - 3 Oct 2016
Event2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 - San Diego, United States
Duration: 31 Oct 20157 Nov 2015

Other

Other2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
CountryUnited States
CitySan Diego
Period31/10/157/11/15

Fingerprint

Gadolinium
Optical Imaging
pinholes
gadolinium
Nanoparticles
Fluorescence
X-Rays
Imaging techniques
X rays
fluorescence
nanoparticles
dosage
x ray fluorescence
x rays
water
Dosimetry
filters
Water
x ray sources
x ray spectra

Cite this

Jung, S., Sung, W., & Ye, S-J. (2016). Monte Carlo study for pinhole X-ray fluorescence imaging of gadolinium nanoparticles. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 [7582247] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2015.7582247
Jung, Seongmoon ; Sung, Wonmo ; Ye, Sung-Joon. / Monte Carlo study for pinhole X-ray fluorescence imaging of gadolinium nanoparticles. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016.
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abstract = "This work aims to develop a Monte Carlo (MC) model of pinhole x-ray fluorescence imaging for gadolinium nanoparticles (GdNPs) in a cylindrical water phantom and to derive the relationship between imaging dose and quality for different x-ray spectra. We constructed four Gd columns in the water phantom which had different concentrations: 0.01{\%}, 0.03{\%}, 0.06{\%}, and 0.09{\%} by weight of Gd The water phantom with and without Gd columns were irradiated by fan beams of 51 keV and 60 keV monochromatic x-rays. The spectrum of 110 kVp polychromatic x-rays with 3-mm-thick Be and 2-mm-thick Al filter was extracted from SpekCalc code. 110 kVp x-rays with 3-mm-thick Be and 0.3-mm-thick W filter were also used to irradiate the phantoms. The images were evaluated by Contrast to Noise Ratio (CNR). The imaging dose to water of each x-ray source was also calculated by MC simulations. Finally, we could estimate the dose required to achieve CNR=3. The spectrum of 110 kVp x-ray with 3-mm-thick Be and 0.3-mm-thick Wfilter was shown to be the best incident x-ray in terms of reducing dose while achieve high quality image. The MC simulations demonstrated the feasibility of pinhole x-ray fluorescence imaging of Gd nanoparticles.",
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Jung, S, Sung, W & Ye, S-J 2016, Monte Carlo study for pinhole X-ray fluorescence imaging of gadolinium nanoparticles. in 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015., 7582247, Institute of Electrical and Electronics Engineers Inc., 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, San Diego, United States, 31/10/15. https://doi.org/10.1109/NSSMIC.2015.7582247

Monte Carlo study for pinhole X-ray fluorescence imaging of gadolinium nanoparticles. / Jung, Seongmoon; Sung, Wonmo; Ye, Sung-Joon.

2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016. 7582247.

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

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N2 - This work aims to develop a Monte Carlo (MC) model of pinhole x-ray fluorescence imaging for gadolinium nanoparticles (GdNPs) in a cylindrical water phantom and to derive the relationship between imaging dose and quality for different x-ray spectra. We constructed four Gd columns in the water phantom which had different concentrations: 0.01%, 0.03%, 0.06%, and 0.09% by weight of Gd The water phantom with and without Gd columns were irradiated by fan beams of 51 keV and 60 keV monochromatic x-rays. The spectrum of 110 kVp polychromatic x-rays with 3-mm-thick Be and 2-mm-thick Al filter was extracted from SpekCalc code. 110 kVp x-rays with 3-mm-thick Be and 0.3-mm-thick W filter were also used to irradiate the phantoms. The images were evaluated by Contrast to Noise Ratio (CNR). The imaging dose to water of each x-ray source was also calculated by MC simulations. Finally, we could estimate the dose required to achieve CNR=3. The spectrum of 110 kVp x-ray with 3-mm-thick Be and 0.3-mm-thick Wfilter was shown to be the best incident x-ray in terms of reducing dose while achieve high quality image. The MC simulations demonstrated the feasibility of pinhole x-ray fluorescence imaging of Gd nanoparticles.

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PB - Institute of Electrical and Electronics Engineers Inc.

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Jung S, Sung W, Ye S-J. Monte Carlo study for pinhole X-ray fluorescence imaging of gadolinium nanoparticles. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc. 2016. 7582247 https://doi.org/10.1109/NSSMIC.2015.7582247