Modulation of collagen-induced arthritis by IL-4 and dexamethasone: The synergistic effect of IL-4 and dexamethasone on the resolution of CIA

Insoo Kang, Won Woo Lee, Yong Soon Lee

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We investigated effects of IL-4, dexamethasone (DXM), and the combination of IL-4 and DXM, low- or high-dose, on collagen-induced arthritis (CIA) in DBA/1 mice and correlated severity of arthritis with changes in IL- 10 and IFN-γ. Compared with control mice, mice treated with IL-4 had increased IL-10 with the same degree of arthritis, whereas mice treated with high-dose DXM had decreased IL-10 and increased IFN-γ production with less severe arthritis. Mice treated with low-dose DXM showed the absence of IL-10 and increased IFN-γ production with a trend toward the resolution of arthritis. Mice treated with IL-4 and low-dose DXM had neither IL-10 nor IFN- γ production but revealed less severe arthritis, compared with mice treated with low-dose DXM alone. These results suggest that the beneficial effects of high-dose DXM and the combination of IL-4 and DXM on CIA are independent of IL-10 and IFN-γ. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalImmunopharmacology
Volume49
Issue number3
DOIs
StatePublished - 5 Oct 2000

Keywords

  • CIA
  • IL-4
  • Steroid

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