Abstract
We investigated effects of IL-4, dexamethasone (DXM), and the combination of IL-4 and DXM, low- or high-dose, on collagen-induced arthritis (CIA) in DBA/1 mice and correlated severity of arthritis with changes in IL- 10 and IFN-γ. Compared with control mice, mice treated with IL-4 had increased IL-10 with the same degree of arthritis, whereas mice treated with high-dose DXM had decreased IL-10 and increased IFN-γ production with less severe arthritis. Mice treated with low-dose DXM showed the absence of IL-10 and increased IFN-γ production with a trend toward the resolution of arthritis. Mice treated with IL-4 and low-dose DXM had neither IL-10 nor IFN- γ production but revealed less severe arthritis, compared with mice treated with low-dose DXM alone. These results suggest that the beneficial effects of high-dose DXM and the combination of IL-4 and DXM on CIA are independent of IL-10 and IFN-γ. (C) 2000 Elsevier Science B.V.
Original language | English |
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Pages (from-to) | 317-324 |
Number of pages | 8 |
Journal | Immunopharmacology |
Volume | 49 |
Issue number | 3 |
DOIs | |
State | Published - 2000 |
Bibliographical note
Funding Information:This work was supported by the Hallym University Medical Center Research Grant.
Keywords
- CIA
- IL-4
- Steroid