Modes of regulation of ubiquitin-mediated protein degradation

Daniel Kornitzer, Aaron Ciechanover

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

The ubiquitin-proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin-mediated degradation is involved in physiological regulation of many cellular processes, including cell cycle progression, differentiation, and signal transduction. Here, we review the basic mechanisms of the ubiquitin system and the various ways in which ubiquitin-mediated degrada-tion can be modulated by physiolocical signals.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Cellular Physiology
Volume182
Issue number1
DOIs
StatePublished - 1 Jan 2000

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Ubiquitin
Proteolysis
Degradation
Proteins
Signal transduction
Proteasome Endopeptidase Complex
Signal Transduction
Cell Cycle
Cells

Cite this

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Modes of regulation of ubiquitin-mediated protein degradation. / Kornitzer, Daniel; Ciechanover, Aaron.

In: Journal of Cellular Physiology, Vol. 182, No. 1, 01.01.2000, p. 1-11.

Research output: Contribution to journalArticle

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