Methimazole-induced bullous systemic lupus erythematosus: A case report

Ji Yeon Seo, Hee Jin Byun, Kwang Hyun Cho, Eun Bong Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Bullous systemic lupus erythematosus (SLE) is a kind of LE-non-specific bullous skin disease that is rarely induced by a medication. We describe the first case of bullous SLE to develop after administration of methimazole. A 31-yr-old woman presented with generalized erythematous patches, multiple bullae, arthralgia, fever, conjunctivitis, and hemolytic anemia. Biopsy of her bulla showed linear deposition of lgG, lgA, C3, fibrinogen, and C1q at dermo-epidermal junction. She was diagnosed as bullous SLE and treated with prednisolone, dapsone, hydroxychloroquine, and methotrexate. Our experience suggests that SLE should be considered as a differential diagnosis when bullous skin lesions develop in patients being treated for hyperthyroidism.

Original languageEnglish
Pages (from-to)818-821
Number of pages4
JournalJournal of Korean Medical Science
Volume27
Issue number7
DOIs
StatePublished - 1 Jul 2012

Fingerprint

Methimazole
Systemic Lupus Erythematosus
Blister
Vesiculobullous Skin Diseases
Hydroxychloroquine
Dapsone
Conjunctivitis
Hemolytic Anemia
Arthralgia
Hyperthyroidism
Prednisolone
Methotrexate
Fibrinogen
Differential Diagnosis
Fever
Biopsy
Skin

Keywords

  • Bullous systemic lupus erythematosus
  • Drug-induced lupus erythematosus
  • Graves disease
  • Methimazole

Cite this

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abstract = "Bullous systemic lupus erythematosus (SLE) is a kind of LE-non-specific bullous skin disease that is rarely induced by a medication. We describe the first case of bullous SLE to develop after administration of methimazole. A 31-yr-old woman presented with generalized erythematous patches, multiple bullae, arthralgia, fever, conjunctivitis, and hemolytic anemia. Biopsy of her bulla showed linear deposition of lgG, lgA, C3, fibrinogen, and C1q at dermo-epidermal junction. She was diagnosed as bullous SLE and treated with prednisolone, dapsone, hydroxychloroquine, and methotrexate. Our experience suggests that SLE should be considered as a differential diagnosis when bullous skin lesions develop in patients being treated for hyperthyroidism.",
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Methimazole-induced bullous systemic lupus erythematosus : A case report. / Seo, Ji Yeon; Byun, Hee Jin; Cho, Kwang Hyun; Lee, Eun Bong.

In: Journal of Korean Medical Science, Vol. 27, No. 7, 01.07.2012, p. 818-821.

Research output: Contribution to journalArticle

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T1 - Methimazole-induced bullous systemic lupus erythematosus

T2 - A case report

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AU - Lee, Eun Bong

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AB - Bullous systemic lupus erythematosus (SLE) is a kind of LE-non-specific bullous skin disease that is rarely induced by a medication. We describe the first case of bullous SLE to develop after administration of methimazole. A 31-yr-old woman presented with generalized erythematous patches, multiple bullae, arthralgia, fever, conjunctivitis, and hemolytic anemia. Biopsy of her bulla showed linear deposition of lgG, lgA, C3, fibrinogen, and C1q at dermo-epidermal junction. She was diagnosed as bullous SLE and treated with prednisolone, dapsone, hydroxychloroquine, and methotrexate. Our experience suggests that SLE should be considered as a differential diagnosis when bullous skin lesions develop in patients being treated for hyperthyroidism.

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