Metabotropic glutamate receptor trafficking

Young Ho Suh, Kai Chang, Katherine W. Roche

Research output: Contribution to journalReview articleResearchpeer-review

5 Citations (Scopus)

Abstract

The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system. Trafficking of mGlu receptors in and out of the synaptic plasma membrane is a fundamental mechanism modulating excitatory synaptic function through regulation of receptor abundance, desensitization, and signaling profiles. In this review, we cover the regulatory mechanisms determining surface expression and endocytosis of mGlu receptors, with particular focus on post-translational modifications and receptor-protein interactions. The literature we review broadens our insight into the precise events defining the expression of functional mGlu receptors at synapses, and will likely contribute to the successful development of novel therapeutic targets for a variety of developmental, neurological, and psychiatric disorders.

Original languageEnglish
Pages (from-to)10-24
Number of pages15
JournalMolecular and Cellular Neuroscience
Volume91
DOIs
StatePublished - 1 Sep 2018

Fingerprint

Metabotropic Glutamate Receptors
Synaptic Membranes
Neuronal Plasticity
Post Translational Protein Processing
G-Protein-Coupled Receptors
Endocytosis
Nervous System Diseases
Synaptic Transmission
Synapses
Neurotransmitter Agents
Psychiatry
Glutamic Acid
Central Nervous System
Cell Membrane
Therapeutics

Keywords

  • Endocytosis
  • Metabotropic glutamate receptors
  • Phosphorylation
  • Post-translational modification
  • Protein-protein interaction
  • Trafficking

Cite this

Suh, Young Ho ; Chang, Kai ; Roche, Katherine W. / Metabotropic glutamate receptor trafficking. In: Molecular and Cellular Neuroscience. 2018 ; Vol. 91. pp. 10-24.
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Metabotropic glutamate receptor trafficking. / Suh, Young Ho; Chang, Kai; Roche, Katherine W.

In: Molecular and Cellular Neuroscience, Vol. 91, 01.09.2018, p. 10-24.

Research output: Contribution to journalReview articleResearchpeer-review

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