Metabolic tumor volumes by [ 18 f]-fluorodeoxyglucose pet/ct correlate with occult metastasis in oral squamous cell carcinoma of the tongue

Man Ki Chung, Han Sin Jeong, Young Ik Son, Yoon Kyoung So, Ga Young Park, Joon Young Choi, Seung Hyup Hyun, Hyungjin Kim, Young Hyeh Ko, Chung Hwan Baek

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue. Methods: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV max ] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM. Results: Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of ≤6.0 ml (57.1% vs. 13.7%, hazard ratio 8.33, 95% confidence interval, 1.95-35.6, P = 0.009). Lymphovascular invasion and SUV max showed only trends toward significance (P = 0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95% confidence interval, 1.05-2842.86, P = 0.04). Conclusions: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.

Original languageEnglish
Pages (from-to)3111-3117
Number of pages7
JournalAnnals of Surgical Oncology
Volume16
Issue number11
DOIs
StatePublished - 1 Nov 2009
Externally publishedYes

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Pets
Tumor Burden
Tongue
Squamous Cell Carcinoma
Neoplasm Metastasis
Neck Dissection
Confidence Intervals
Fluorodeoxyglucose F18
Physical Examination
Neoplasms
Multivariate Analysis
Biopsy

Cite this

Chung, Man Ki ; Jeong, Han Sin ; Son, Young Ik ; So, Yoon Kyoung ; Park, Ga Young ; Choi, Joon Young ; Hyun, Seung Hyup ; Kim, Hyungjin ; Ko, Young Hyeh ; Baek, Chung Hwan. / Metabolic tumor volumes by [ 18 f]-fluorodeoxyglucose pet/ct correlate with occult metastasis in oral squamous cell carcinoma of the tongue In: Annals of Surgical Oncology. 2009 ; Vol. 16, No. 11. pp. 3111-3117.
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title = "Metabolic tumor volumes by [ 18 f]-fluorodeoxyglucose pet/ct correlate with occult metastasis in oral squamous cell carcinoma of the tongue",
abstract = "Background: To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue. Methods: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV max ] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM. Results: Twelve (27.9{\%}) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of ≤6.0 ml (57.1{\%} vs. 13.7{\%}, hazard ratio 8.33, 95{\%} confidence interval, 1.95-35.6, P = 0.009). Lymphovascular invasion and SUV max showed only trends toward significance (P = 0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95{\%} confidence interval, 1.05-2842.86, P = 0.04). Conclusions: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.",
author = "Chung, {Man Ki} and Jeong, {Han Sin} and Son, {Young Ik} and So, {Yoon Kyoung} and Park, {Ga Young} and Choi, {Joon Young} and Hyun, {Seung Hyup} and Hyungjin Kim and Ko, {Young Hyeh} and Baek, {Chung Hwan}",
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Metabolic tumor volumes by [ 18 f]-fluorodeoxyglucose pet/ct correlate with occult metastasis in oral squamous cell carcinoma of the tongue . / Chung, Man Ki; Jeong, Han Sin; Son, Young Ik; So, Yoon Kyoung; Park, Ga Young; Choi, Joon Young; Hyun, Seung Hyup; Kim, Hyungjin; Ko, Young Hyeh; Baek, Chung Hwan.

In: Annals of Surgical Oncology, Vol. 16, No. 11, 01.11.2009, p. 3111-3117.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metabolic tumor volumes by [ 18 f]-fluorodeoxyglucose pet/ct correlate with occult metastasis in oral squamous cell carcinoma of the tongue

AU - Chung, Man Ki

AU - Jeong, Han Sin

AU - Son, Young Ik

AU - So, Yoon Kyoung

AU - Park, Ga Young

AU - Choi, Joon Young

AU - Hyun, Seung Hyup

AU - Kim, Hyungjin

AU - Ko, Young Hyeh

AU - Baek, Chung Hwan

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Background: To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue. Methods: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV max ] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM. Results: Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of ≤6.0 ml (57.1% vs. 13.7%, hazard ratio 8.33, 95% confidence interval, 1.95-35.6, P = 0.009). Lymphovascular invasion and SUV max showed only trends toward significance (P = 0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95% confidence interval, 1.05-2842.86, P = 0.04). Conclusions: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.

AB - Background: To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue. Methods: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV max ] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM. Results: Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of ≤6.0 ml (57.1% vs. 13.7%, hazard ratio 8.33, 95% confidence interval, 1.95-35.6, P = 0.009). Lymphovascular invasion and SUV max showed only trends toward significance (P = 0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95% confidence interval, 1.05-2842.86, P = 0.04). Conclusions: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.

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U2 - 10.1245/s10434-009-0621-3

DO - 10.1245/s10434-009-0621-3

M3 - Article

C2 - 19609618

AN - SCOPUS:70350414203

VL - 16

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JO - Annals of surgical oncology

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