Metabolic syndrome is associated with venous thromboembolism in the Korean population

Moon Ju Jang, Won il Choi, Soo Mee Bang, Taeseung Lee, Yeo Kyeoung Kim, Walter Ageno, Doyeun Oh

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background - The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports have also suggested the association between MS and venous thromboembolism (VTE). Methods and Results - In this case-control study, we investigated the association between MS and VTE in Korean patients. Patients with objectively diagnosed VTE and healthy control subjects underwent clinical assessment for the presence of MS according to the National Cholesterol Education Adult Treatment Panel III criteria modified with body mass index (WHO Asian Pacific Perspective, 2000). The presence of known risk factors for VTE was ascertained. Patients with VTE secondary to cancer were excluded. The prevalence of MS was compared between VTE group and controls. Two hundred eight VTE patients and 300 controls were assessed. VTE was idiopathic in 91 patients and secondary to a known risk factor in 117. The prevalence of MS was significantly higher in VTE patients (47.6%) than in controls (37.7%) (OR: 1.50; 95% CI: 1.05 to 2.15, P=0.026). After adjusting for age, sex, and smoking status, metabolic MS remained independently associated with VTE (OR: 1.56; 95% CI: 1.07 to 2.27, P=0.020). In the subgroup analysis, MS was also independently associated with idiopathic VTE (OR: 1.71; 95% CI: 1.04 to 2.81, P=0.033), but not with secondary VTE (OR: 1.43; 95% CI: 0.91 to 2.99, P=0.121). Multivariate analysis demonstrated that high BMI (OR: 1.70, 95% CI: 1.01 to 2.87), decreased HDL cholesterol (OR: 1.99, 95% CI: 1.17 to 3.39), and elevated fasting glucose levels (OR: 2.31; 95% CI: 1.35 to 3.94) were associated with idiopathic VTE. Conclusion - MS is associated with VTE and in particular with idiopathic VTE in the Korean population.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume29
Issue number3
DOIs
StatePublished - 1 Mar 2009

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Venous Thromboembolism
Population
Thromboembolism
HDL Cholesterol
Case-Control Studies
Fasting

Keywords

  • Venous thromboembolism metabolic syndrome

Cite this

Jang, Moon Ju ; Choi, Won il ; Bang, Soo Mee ; Lee, Taeseung ; Kim, Yeo Kyeoung ; Ageno, Walter ; Oh, Doyeun. / Metabolic syndrome is associated with venous thromboembolism in the Korean population. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2009 ; Vol. 29, No. 3. pp. 311-315.
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title = "Metabolic syndrome is associated with venous thromboembolism in the Korean population",
abstract = "Background - The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports have also suggested the association between MS and venous thromboembolism (VTE). Methods and Results - In this case-control study, we investigated the association between MS and VTE in Korean patients. Patients with objectively diagnosed VTE and healthy control subjects underwent clinical assessment for the presence of MS according to the National Cholesterol Education Adult Treatment Panel III criteria modified with body mass index (WHO Asian Pacific Perspective, 2000). The presence of known risk factors for VTE was ascertained. Patients with VTE secondary to cancer were excluded. The prevalence of MS was compared between VTE group and controls. Two hundred eight VTE patients and 300 controls were assessed. VTE was idiopathic in 91 patients and secondary to a known risk factor in 117. The prevalence of MS was significantly higher in VTE patients (47.6{\%}) than in controls (37.7{\%}) (OR: 1.50; 95{\%} CI: 1.05 to 2.15, P=0.026). After adjusting for age, sex, and smoking status, metabolic MS remained independently associated with VTE (OR: 1.56; 95{\%} CI: 1.07 to 2.27, P=0.020). In the subgroup analysis, MS was also independently associated with idiopathic VTE (OR: 1.71; 95{\%} CI: 1.04 to 2.81, P=0.033), but not with secondary VTE (OR: 1.43; 95{\%} CI: 0.91 to 2.99, P=0.121). Multivariate analysis demonstrated that high BMI (OR: 1.70, 95{\%} CI: 1.01 to 2.87), decreased HDL cholesterol (OR: 1.99, 95{\%} CI: 1.17 to 3.39), and elevated fasting glucose levels (OR: 2.31; 95{\%} CI: 1.35 to 3.94) were associated with idiopathic VTE. Conclusion - MS is associated with VTE and in particular with idiopathic VTE in the Korean population.",
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Metabolic syndrome is associated with venous thromboembolism in the Korean population. / Jang, Moon Ju; Choi, Won il; Bang, Soo Mee; Lee, Taeseung; Kim, Yeo Kyeoung; Ageno, Walter; Oh, Doyeun.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 29, No. 3, 01.03.2009, p. 311-315.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metabolic syndrome is associated with venous thromboembolism in the Korean population

AU - Jang, Moon Ju

AU - Choi, Won il

AU - Bang, Soo Mee

AU - Lee, Taeseung

AU - Kim, Yeo Kyeoung

AU - Ageno, Walter

AU - Oh, Doyeun

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background - The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports have also suggested the association between MS and venous thromboembolism (VTE). Methods and Results - In this case-control study, we investigated the association between MS and VTE in Korean patients. Patients with objectively diagnosed VTE and healthy control subjects underwent clinical assessment for the presence of MS according to the National Cholesterol Education Adult Treatment Panel III criteria modified with body mass index (WHO Asian Pacific Perspective, 2000). The presence of known risk factors for VTE was ascertained. Patients with VTE secondary to cancer were excluded. The prevalence of MS was compared between VTE group and controls. Two hundred eight VTE patients and 300 controls were assessed. VTE was idiopathic in 91 patients and secondary to a known risk factor in 117. The prevalence of MS was significantly higher in VTE patients (47.6%) than in controls (37.7%) (OR: 1.50; 95% CI: 1.05 to 2.15, P=0.026). After adjusting for age, sex, and smoking status, metabolic MS remained independently associated with VTE (OR: 1.56; 95% CI: 1.07 to 2.27, P=0.020). In the subgroup analysis, MS was also independently associated with idiopathic VTE (OR: 1.71; 95% CI: 1.04 to 2.81, P=0.033), but not with secondary VTE (OR: 1.43; 95% CI: 0.91 to 2.99, P=0.121). Multivariate analysis demonstrated that high BMI (OR: 1.70, 95% CI: 1.01 to 2.87), decreased HDL cholesterol (OR: 1.99, 95% CI: 1.17 to 3.39), and elevated fasting glucose levels (OR: 2.31; 95% CI: 1.35 to 3.94) were associated with idiopathic VTE. Conclusion - MS is associated with VTE and in particular with idiopathic VTE in the Korean population.

AB - Background - The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports have also suggested the association between MS and venous thromboembolism (VTE). Methods and Results - In this case-control study, we investigated the association between MS and VTE in Korean patients. Patients with objectively diagnosed VTE and healthy control subjects underwent clinical assessment for the presence of MS according to the National Cholesterol Education Adult Treatment Panel III criteria modified with body mass index (WHO Asian Pacific Perspective, 2000). The presence of known risk factors for VTE was ascertained. Patients with VTE secondary to cancer were excluded. The prevalence of MS was compared between VTE group and controls. Two hundred eight VTE patients and 300 controls were assessed. VTE was idiopathic in 91 patients and secondary to a known risk factor in 117. The prevalence of MS was significantly higher in VTE patients (47.6%) than in controls (37.7%) (OR: 1.50; 95% CI: 1.05 to 2.15, P=0.026). After adjusting for age, sex, and smoking status, metabolic MS remained independently associated with VTE (OR: 1.56; 95% CI: 1.07 to 2.27, P=0.020). In the subgroup analysis, MS was also independently associated with idiopathic VTE (OR: 1.71; 95% CI: 1.04 to 2.81, P=0.033), but not with secondary VTE (OR: 1.43; 95% CI: 0.91 to 2.99, P=0.121). Multivariate analysis demonstrated that high BMI (OR: 1.70, 95% CI: 1.01 to 2.87), decreased HDL cholesterol (OR: 1.99, 95% CI: 1.17 to 3.39), and elevated fasting glucose levels (OR: 2.31; 95% CI: 1.35 to 3.94) were associated with idiopathic VTE. Conclusion - MS is associated with VTE and in particular with idiopathic VTE in the Korean population.

KW - Venous thromboembolism metabolic syndrome

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U2 - 10.1161/ATVBAHA.109.184085

DO - 10.1161/ATVBAHA.109.184085

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