MeCpG island hypermethylation in gastric carcinoma and its premalignant lesions

Research output: Contribution to journalReview articleResearchpeer-review

13 Citations (Scopus)

Abstract

Gastric cancers arise through a multistep process characterized by the progressive accumulation of molecular alterations in which genetic and epigenetic mechanisms have been implicated. Gastric cancer is one of the human malignancies in which aberrant promoter CpG island hypermethylation is frequently found. Helicobacter pylori and Epstein-Barr virus, which are known carcinogens for gastric cancer, are closely associated with enhanced hypermethylation of CpG island loci in gastric non-neoplastic epithelial cells and cancer cells, respectively. Aberrant CpG island hypermethylation occurs early in the multistep cascade of gastric carcinogenesis and tends to increase with the step-wise progression of the lesion. Approximately 400 genes that are actively expressed in normal gastric epithelial cells are estimated to be inactivated in gastric cancers as a result of promoter CpG island hypermethylation. In this review, a variety of information is summarized regarding CpG island hypermethylation in gastric cancer.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalKorean Journal of Pathology
Volume46
Issue number1
DOIs
StatePublished - 1 Feb 2012

Fingerprint

CpG Islands
Islands
Stomach Neoplasms
Stomach
Carcinoma
Epithelial Cells
Human Herpesvirus 4
Epigenomics
Helicobacter pylori
Carcinogens
Neoplasms
Carcinogenesis
Genes

Keywords

  • CpG island
  • DNA methylation
  • Gastric cancer
  • Intestinal metaplasia

Cite this

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title = "MeCpG island hypermethylation in gastric carcinoma and its premalignant lesions",
abstract = "Gastric cancers arise through a multistep process characterized by the progressive accumulation of molecular alterations in which genetic and epigenetic mechanisms have been implicated. Gastric cancer is one of the human malignancies in which aberrant promoter CpG island hypermethylation is frequently found. Helicobacter pylori and Epstein-Barr virus, which are known carcinogens for gastric cancer, are closely associated with enhanced hypermethylation of CpG island loci in gastric non-neoplastic epithelial cells and cancer cells, respectively. Aberrant CpG island hypermethylation occurs early in the multistep cascade of gastric carcinogenesis and tends to increase with the step-wise progression of the lesion. Approximately 400 genes that are actively expressed in normal gastric epithelial cells are estimated to be inactivated in gastric cancers as a result of promoter CpG island hypermethylation. In this review, a variety of information is summarized regarding CpG island hypermethylation in gastric cancer.",
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MeCpG island hypermethylation in gastric carcinoma and its premalignant lesions. / Kang, Gyeonghoon.

In: Korean Journal of Pathology, Vol. 46, No. 1, 01.02.2012, p. 1-9.

Research output: Contribution to journalReview articleResearchpeer-review

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