MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease

Kwon-Wook Joo, Young Hwan Hwang, Hyeon Kim Jae, Kook-Hwan Oh, Hyunho Kim, Doo Shin Hyoung, Woo Kyung Chung, Jaeseok Yang, Kyong Soo Park, Curie Ahn

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Abstract

Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP-1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalJournal of Korean Medical Science
Volume22
Issue number4
StatePublished - 1 Aug 2007

Keywords

  • Diabetes mellitus, type 2
  • Diabetic nephropathies
  • Kidney failure, chronic
  • Monocyte chemoattractant proteins
  • Polymorphism, single nucleotide polymorphisms
  • RANTES

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