Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients

You Sun Kim, Young Ho Kim, Byong Duk Ye, Dong Won Park, Ji Won Kim, Dong Soo Han

Research output: Contribution to journalArticle

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Abstract

Background: Mannose-binding lectin (MBL) is a pattern-recognition molecule and an important component of the innate defense system. Anti- Saccharomyces cerevisiae antibody (ASCA) is a well known serologic marker of Crohn's disease (CD). This study aimed to investigate the association between MBL, ASCA, and clinical features in Korean CD patients. Method: Two hundred and eighty-three well-characterized CD patients were included. MBL concentrations, serum IgG and IgA concentrations of ASCA were determined by ELISA. Low MBL concentrations were defined as serum MBL concentrations <. 500. ng/ml. Result: Low MBL concentrations were observed in 41 CD patients (14.5%). No differences in MBL concentrations were detected according to the age at diagnosis, behavior, or the location of patients with CD. MBL concentrations and the frequency of low MBL concentrations did not differ according to ASCA positivity. The presence of perianal involvement (p = 0.043), younger age at diagnosis (p = 0.021), and intestinal surgery (p = 0.047) were more frequently associated with ASCA positive patients. Conclusion: MBL concentration is not associated with clinical features of CD patients or ASCA positivity. ASCA positivity is associated with a severe clinical course in Korean CD patients.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalClinica Chimica Acta
Volume429
DOIs
StatePublished - 15 Feb 2014

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Mannose-Binding Lectin
Crohn Disease
Yeast
Saccharomyces cerevisiae
Antibodies
Mannose-Binding Protein Deficiency
Serum
Surgery
Pattern recognition
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay

Keywords

  • Anti-Saccharomyces cerevisiae antibody
  • Crohn's disease
  • Mannose-binding lectin

Cite this

Kim, You Sun ; Kim, Young Ho ; Ye, Byong Duk ; Park, Dong Won ; Kim, Ji Won ; Han, Dong Soo. / Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients. In: Clinica Chimica Acta. 2014 ; Vol. 429. pp. 206-211.
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abstract = "Background: Mannose-binding lectin (MBL) is a pattern-recognition molecule and an important component of the innate defense system. Anti- Saccharomyces cerevisiae antibody (ASCA) is a well known serologic marker of Crohn's disease (CD). This study aimed to investigate the association between MBL, ASCA, and clinical features in Korean CD patients. Method: Two hundred and eighty-three well-characterized CD patients were included. MBL concentrations, serum IgG and IgA concentrations of ASCA were determined by ELISA. Low MBL concentrations were defined as serum MBL concentrations <. 500. ng/ml. Result: Low MBL concentrations were observed in 41 CD patients (14.5{\%}). No differences in MBL concentrations were detected according to the age at diagnosis, behavior, or the location of patients with CD. MBL concentrations and the frequency of low MBL concentrations did not differ according to ASCA positivity. The presence of perianal involvement (p = 0.043), younger age at diagnosis (p = 0.021), and intestinal surgery (p = 0.047) were more frequently associated with ASCA positive patients. Conclusion: MBL concentration is not associated with clinical features of CD patients or ASCA positivity. ASCA positivity is associated with a severe clinical course in Korean CD patients.",
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Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients. / Kim, You Sun; Kim, Young Ho; Ye, Byong Duk; Park, Dong Won; Kim, Ji Won; Han, Dong Soo.

In: Clinica Chimica Acta, Vol. 429, 15.02.2014, p. 206-211.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients

AU - Kim, You Sun

AU - Kim, Young Ho

AU - Ye, Byong Duk

AU - Park, Dong Won

AU - Kim, Ji Won

AU - Han, Dong Soo

PY - 2014/2/15

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N2 - Background: Mannose-binding lectin (MBL) is a pattern-recognition molecule and an important component of the innate defense system. Anti- Saccharomyces cerevisiae antibody (ASCA) is a well known serologic marker of Crohn's disease (CD). This study aimed to investigate the association between MBL, ASCA, and clinical features in Korean CD patients. Method: Two hundred and eighty-three well-characterized CD patients were included. MBL concentrations, serum IgG and IgA concentrations of ASCA were determined by ELISA. Low MBL concentrations were defined as serum MBL concentrations <. 500. ng/ml. Result: Low MBL concentrations were observed in 41 CD patients (14.5%). No differences in MBL concentrations were detected according to the age at diagnosis, behavior, or the location of patients with CD. MBL concentrations and the frequency of low MBL concentrations did not differ according to ASCA positivity. The presence of perianal involvement (p = 0.043), younger age at diagnosis (p = 0.021), and intestinal surgery (p = 0.047) were more frequently associated with ASCA positive patients. Conclusion: MBL concentration is not associated with clinical features of CD patients or ASCA positivity. ASCA positivity is associated with a severe clinical course in Korean CD patients.

AB - Background: Mannose-binding lectin (MBL) is a pattern-recognition molecule and an important component of the innate defense system. Anti- Saccharomyces cerevisiae antibody (ASCA) is a well known serologic marker of Crohn's disease (CD). This study aimed to investigate the association between MBL, ASCA, and clinical features in Korean CD patients. Method: Two hundred and eighty-three well-characterized CD patients were included. MBL concentrations, serum IgG and IgA concentrations of ASCA were determined by ELISA. Low MBL concentrations were defined as serum MBL concentrations <. 500. ng/ml. Result: Low MBL concentrations were observed in 41 CD patients (14.5%). No differences in MBL concentrations were detected according to the age at diagnosis, behavior, or the location of patients with CD. MBL concentrations and the frequency of low MBL concentrations did not differ according to ASCA positivity. The presence of perianal involvement (p = 0.043), younger age at diagnosis (p = 0.021), and intestinal surgery (p = 0.047) were more frequently associated with ASCA positive patients. Conclusion: MBL concentration is not associated with clinical features of CD patients or ASCA positivity. ASCA positivity is associated with a severe clinical course in Korean CD patients.

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