Management of cardiogenic shock complicating myocardial infarction

Alexandre Mebazaa, Alain Combes, Sean van Diepen, Alexa Hollinger, Jaon N. Katz, Giovanni Landoni, Ludhmila Abrahao Hajjar, Johan Lassus, Guillaume Lebreton, Gilles Montalescot, Jin Joo Park, Susanna Price, Alessandro Sionis, Demetris Yannopolos, Veli Pekka Harjola, Bruno Levy, Holger Thiele

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Up to 10% of acute coronary syndromes are complicated by cardiogenic shock (CS) with contemporary mortality rates of 40–50%. The extent of ischemic myocardium has a profound impact on the initial, in-hospital, and post-discharge management and prognosis in this patient population. Individualized patient risk assessment plays an important role in determining appropriate revascularization, drug treatment with inotropes and vasopressors, mechanical circulatory support, intensive care support of other organ systems, hospital level of care triage, and allocation of clinical resources. This review will outline the underlying causes and diagnostic criteria, pathophysiology, and treatment of CS complicating acute coronary syndromes with a focus on (a) potential therapeutic issues from the perspective an interventional cardiologist, an emergency physician, and an intensive care physician, (b) the type of revascularization, and (c) new therapeutic advancements in pharmacologic and mechanical percutaneous circulatory support.

Original languageEnglish
Pages (from-to)760-773
Number of pages14
JournalIntensive Care Medicine
Volume44
Issue number6
DOIs
StatePublished - 1 Jun 2018

Fingerprint

Cardiogenic Shock
Myocardial Infarction
Critical Care
Acute Coronary Syndrome
Physicians
Resource Allocation
Triage
Therapeutics
Myocardium
Emergencies
Mortality
Pharmaceutical Preparations
Population

Keywords

  • Acute myocardial infarction
  • Cardiogenic shock
  • Catecholamines
  • Mechanical circulatory support

Cite this

Mebazaa, A., Combes, A., van Diepen, S., Hollinger, A., Katz, J. N., Landoni, G., ... Thiele, H. (2018). Management of cardiogenic shock complicating myocardial infarction. Intensive Care Medicine, 44(6), 760-773. https://doi.org/10.1007/s00134-018-5214-9
Mebazaa, Alexandre ; Combes, Alain ; van Diepen, Sean ; Hollinger, Alexa ; Katz, Jaon N. ; Landoni, Giovanni ; Hajjar, Ludhmila Abrahao ; Lassus, Johan ; Lebreton, Guillaume ; Montalescot, Gilles ; Park, Jin Joo ; Price, Susanna ; Sionis, Alessandro ; Yannopolos, Demetris ; Harjola, Veli Pekka ; Levy, Bruno ; Thiele, Holger. / Management of cardiogenic shock complicating myocardial infarction. In: Intensive Care Medicine. 2018 ; Vol. 44, No. 6. pp. 760-773.
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Mebazaa, A, Combes, A, van Diepen, S, Hollinger, A, Katz, JN, Landoni, G, Hajjar, LA, Lassus, J, Lebreton, G, Montalescot, G, Park, JJ, Price, S, Sionis, A, Yannopolos, D, Harjola, VP, Levy, B & Thiele, H 2018, 'Management of cardiogenic shock complicating myocardial infarction', Intensive Care Medicine, vol. 44, no. 6, pp. 760-773. https://doi.org/10.1007/s00134-018-5214-9

Management of cardiogenic shock complicating myocardial infarction. / Mebazaa, Alexandre; Combes, Alain; van Diepen, Sean; Hollinger, Alexa; Katz, Jaon N.; Landoni, Giovanni; Hajjar, Ludhmila Abrahao; Lassus, Johan; Lebreton, Guillaume; Montalescot, Gilles; Park, Jin Joo; Price, Susanna; Sionis, Alessandro; Yannopolos, Demetris; Harjola, Veli Pekka; Levy, Bruno; Thiele, Holger.

In: Intensive Care Medicine, Vol. 44, No. 6, 01.06.2018, p. 760-773.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Management of cardiogenic shock complicating myocardial infarction

AU - Mebazaa, Alexandre

AU - Combes, Alain

AU - van Diepen, Sean

AU - Hollinger, Alexa

AU - Katz, Jaon N.

AU - Landoni, Giovanni

AU - Hajjar, Ludhmila Abrahao

AU - Lassus, Johan

AU - Lebreton, Guillaume

AU - Montalescot, Gilles

AU - Park, Jin Joo

AU - Price, Susanna

AU - Sionis, Alessandro

AU - Yannopolos, Demetris

AU - Harjola, Veli Pekka

AU - Levy, Bruno

AU - Thiele, Holger

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Up to 10% of acute coronary syndromes are complicated by cardiogenic shock (CS) with contemporary mortality rates of 40–50%. The extent of ischemic myocardium has a profound impact on the initial, in-hospital, and post-discharge management and prognosis in this patient population. Individualized patient risk assessment plays an important role in determining appropriate revascularization, drug treatment with inotropes and vasopressors, mechanical circulatory support, intensive care support of other organ systems, hospital level of care triage, and allocation of clinical resources. This review will outline the underlying causes and diagnostic criteria, pathophysiology, and treatment of CS complicating acute coronary syndromes with a focus on (a) potential therapeutic issues from the perspective an interventional cardiologist, an emergency physician, and an intensive care physician, (b) the type of revascularization, and (c) new therapeutic advancements in pharmacologic and mechanical percutaneous circulatory support.

AB - Up to 10% of acute coronary syndromes are complicated by cardiogenic shock (CS) with contemporary mortality rates of 40–50%. The extent of ischemic myocardium has a profound impact on the initial, in-hospital, and post-discharge management and prognosis in this patient population. Individualized patient risk assessment plays an important role in determining appropriate revascularization, drug treatment with inotropes and vasopressors, mechanical circulatory support, intensive care support of other organ systems, hospital level of care triage, and allocation of clinical resources. This review will outline the underlying causes and diagnostic criteria, pathophysiology, and treatment of CS complicating acute coronary syndromes with a focus on (a) potential therapeutic issues from the perspective an interventional cardiologist, an emergency physician, and an intensive care physician, (b) the type of revascularization, and (c) new therapeutic advancements in pharmacologic and mechanical percutaneous circulatory support.

KW - Acute myocardial infarction

KW - Cardiogenic shock

KW - Catecholamines

KW - Mechanical circulatory support

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U2 - 10.1007/s00134-018-5214-9

DO - 10.1007/s00134-018-5214-9

M3 - Review article

C2 - 29767322

AN - SCOPUS:85047150371

VL - 44

SP - 760

EP - 773

JO - Intensive Care Medicine

JF - Intensive Care Medicine

SN - 0342-4642

IS - 6

ER -

Mebazaa A, Combes A, van Diepen S, Hollinger A, Katz JN, Landoni G et al. Management of cardiogenic shock complicating myocardial infarction. Intensive Care Medicine. 2018 Jun 1;44(6):760-773. https://doi.org/10.1007/s00134-018-5214-9