Malignant conversion and peritoneal dissemination after endoscopic ultrasound-guided ethanol ablation in intraductal papillary mucinous neoplasm of the pancreas

Jin Young Jang, Yoonhyeong Byun, Youngmin Han, Hongbeom Kim, Wooil Kwon

Research output: Contribution to journalArticle

Abstract

Background: With the increasing detection of pancreatic cysts, many centers have applied endoscopic ultrasound-guided pancreatic cyst ablation (EUS-PCA), even in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas based on early promising outcomes. However, long-term effects of ethanol ablation have been rarely reported, especially regarding oncologic outcomes. Methods and Results: We report eight cases of malignancy conversion after EUS-PCA in patients with IPMNs who had worrisome features. Moreover, two patients showed tumor spillage or peritoneal seeding (carcinomatosis) after EUS-PCA. Conclusions: Endoscopic ultrasound-guided pancreatic cyst ablation must not be performed as a treatment for IPMNs, considering adverse results such as tumor spillage and the lack of oncological therapeutic effect.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume26
Issue number10
DOIs
StatePublished - 1 Oct 2019

Keywords

  • Endoscopic ultrasonography
  • Ethanol ablation
  • Pancreatic cyst ablation
  • Pancreatic intraductal papillary mucinous neoplasm

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