Major clinical research advances in gynecologic cancer in 2019

Miseon Kim, Dong Hoon Suh, Kyung Hun Lee, Keun Yong Eom, Jung Yun Lee, Yoo Young Lee, Hanne Falk Hansen, Mansoor Raza Mirza, Jae Weon Kim

Research output: Contribution to journalReview article

Abstract

In 2019, 12 topics were selected as the major research advances in gynecologic oncology. Herein, we first opted to introduce the significant clinical activity of pembrolizumab in women with advanced cervical cancer based on the results of the phase 2 KEYNOTE-158 trial. Thereafter, we reviewed 5 topics, including systemic lymphadenectomy in the advanced stage with no gross residual tumor, secondary cytoreductive surgery in recurrent ovarian cancer according to the results of Gynecologic Oncology Group-213 trial, dose-dense weekly paclitaxel scheduling as first-line chemotherapy, the utility of intraperitoneal therapy in the advanced stage, and an update on poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. Additionally, we conducted a thorough review of emerging data from several clinical trials on PARP inhibitors according to drug, target population, and combined usage. For uterine corpus cancer, we reviewed adjuvant therapy for high-risk disease and chemotherapy in advanced/recurrent disease. For the field of radiation oncology, we discussed the utility of neoadjuvant chemotherapy added to chemoradiotherapy and the treatment of radiation-induced cystitis using hyperbaric oxygen. Finally, we discussed the use of individualized therapy with humanized monoclonal antibodies (trastuzumab emtansine and sacituzumab govitecan-hziy) and combination therapy (fulvestrant plus alpesilib, fulvestrant plus anastrozole, and ribociclib plus endocrine therapy) for women with advanced breast cancer.

Original languageEnglish
Pages (from-to)e48
JournalJournal of Gynecologic Oncology
Volume31
Issue number3
DOIs
StatePublished - 1 May 2020

    Fingerprint

Keywords

  • Adjuvant Therapy
  • Combination Therapy
  • Humanized Monoclonal Antibody
  • Immunotherapy
  • Poly(ADP-ribose) Polymerase Inhibitors

Cite this

Kim, M., Suh, D. H., Lee, K. H., Eom, K. Y., Lee, J. Y., Lee, Y. Y., Hansen, H. F., Mirza, M. R., & Kim, J. W. (2020). Major clinical research advances in gynecologic cancer in 2019. Journal of Gynecologic Oncology, 31(3), e48. https://doi.org/10.3802/jgo.2020.31.e48