Lymphadenectomy alone is a feasible option in managing incidentally-detected early-stage cervical cancer after simple hysterectomy without intermediate-risk factors: An application of the concept of less radical surgery.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To assess the feasibility of less radical surgery in patients with incidentally-detected cervical cancer at simple hysterectomy. High-risk factors (HFs) were evaluated in 104 patients who underwent radical hysterectomy and lymphadenectomy for the treatment of stage IA1-IB1 cervical cancer according to intermediate-risk factors (IFs). Thirty-three patients without IFs had no HFs. As the number of IFs increased, the number of HFs increased (p=0.009). Multivariate analysis revealed that lymph node metastasis was the only independent risk factor for parametrial involvement (hazard ratio, 31.3; 95% confidence interval, 1.6-599.4; p=0.022). An absence of IFs was associated with a longer progression-free survival than the presence of IFs in the subgroup analysis of favorable histologies (p=0.044). HFs could be excluded in stage IA1-IB1 cervical cancer without IFs. Omitting parametrectomy seems a feasible option for selected patients with incidentally-detected early-stage cervical cancer at simple hysterectomy, without IFs.

Original languageEnglish
Pages (from-to)5135-5141
Number of pages7
JournalAnticancer Research
Volume33
Issue number11
StatePublished - 1 Nov 2013

Fingerprint

Lymph Node Excision
Hysterectomy
Uterine Cervical Neoplasms
Disease-Free Survival
Histology
Multivariate Analysis
Lymph Nodes
Confidence Intervals
Neoplasm Metastasis

Cite this

@article{b731ecfae71b4d41a1c3736fd86383d7,
title = "Lymphadenectomy alone is a feasible option in managing incidentally-detected early-stage cervical cancer after simple hysterectomy without intermediate-risk factors: An application of the concept of less radical surgery.",
abstract = "To assess the feasibility of less radical surgery in patients with incidentally-detected cervical cancer at simple hysterectomy. High-risk factors (HFs) were evaluated in 104 patients who underwent radical hysterectomy and lymphadenectomy for the treatment of stage IA1-IB1 cervical cancer according to intermediate-risk factors (IFs). Thirty-three patients without IFs had no HFs. As the number of IFs increased, the number of HFs increased (p=0.009). Multivariate analysis revealed that lymph node metastasis was the only independent risk factor for parametrial involvement (hazard ratio, 31.3; 95{\%} confidence interval, 1.6-599.4; p=0.022). An absence of IFs was associated with a longer progression-free survival than the presence of IFs in the subgroup analysis of favorable histologies (p=0.044). HFs could be excluded in stage IA1-IB1 cervical cancer without IFs. Omitting parametrectomy seems a feasible option for selected patients with incidentally-detected early-stage cervical cancer at simple hysterectomy, without IFs.",
author = "Jeon, {Hye Won} and Suh, {Dong Hoon} and Kidong Kim and No, {Jae Hong} and Kim, {Yong Beom}",
year = "2013",
month = "11",
day = "1",
language = "English",
volume = "33",
pages = "5135--5141",
journal = "Anticancer research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "11",

}

TY - JOUR

T1 - Lymphadenectomy alone is a feasible option in managing incidentally-detected early-stage cervical cancer after simple hysterectomy without intermediate-risk factors

T2 - An application of the concept of less radical surgery.

AU - Jeon, Hye Won

AU - Suh, Dong Hoon

AU - Kim, Kidong

AU - No, Jae Hong

AU - Kim, Yong Beom

PY - 2013/11/1

Y1 - 2013/11/1

N2 - To assess the feasibility of less radical surgery in patients with incidentally-detected cervical cancer at simple hysterectomy. High-risk factors (HFs) were evaluated in 104 patients who underwent radical hysterectomy and lymphadenectomy for the treatment of stage IA1-IB1 cervical cancer according to intermediate-risk factors (IFs). Thirty-three patients without IFs had no HFs. As the number of IFs increased, the number of HFs increased (p=0.009). Multivariate analysis revealed that lymph node metastasis was the only independent risk factor for parametrial involvement (hazard ratio, 31.3; 95% confidence interval, 1.6-599.4; p=0.022). An absence of IFs was associated with a longer progression-free survival than the presence of IFs in the subgroup analysis of favorable histologies (p=0.044). HFs could be excluded in stage IA1-IB1 cervical cancer without IFs. Omitting parametrectomy seems a feasible option for selected patients with incidentally-detected early-stage cervical cancer at simple hysterectomy, without IFs.

AB - To assess the feasibility of less radical surgery in patients with incidentally-detected cervical cancer at simple hysterectomy. High-risk factors (HFs) were evaluated in 104 patients who underwent radical hysterectomy and lymphadenectomy for the treatment of stage IA1-IB1 cervical cancer according to intermediate-risk factors (IFs). Thirty-three patients without IFs had no HFs. As the number of IFs increased, the number of HFs increased (p=0.009). Multivariate analysis revealed that lymph node metastasis was the only independent risk factor for parametrial involvement (hazard ratio, 31.3; 95% confidence interval, 1.6-599.4; p=0.022). An absence of IFs was associated with a longer progression-free survival than the presence of IFs in the subgroup analysis of favorable histologies (p=0.044). HFs could be excluded in stage IA1-IB1 cervical cancer without IFs. Omitting parametrectomy seems a feasible option for selected patients with incidentally-detected early-stage cervical cancer at simple hysterectomy, without IFs.

UR - http://www.scopus.com/inward/record.url?scp=84891676199&partnerID=8YFLogxK

M3 - Article

C2 - 24222161

AN - SCOPUS:84891676199

VL - 33

SP - 5135

EP - 5141

JO - Anticancer research

JF - Anticancer research

SN - 0250-7005

IS - 11

ER -