Lung metastasis in adenoid cystic carcinoma of the head and neck

Research output: Contribution to journalArticle

1 Scopus citations


Background: Distant metastasis of adenoid cystic carcinoma (ACC) is most commonly identified in the lung, but risk factors are still on debate. Methods: Risk factors for lung metastasis were evaluated by using Cox proportional hazards model and Kaplan–Meier curves. Results: Of 112 patients, 48% had distant metastasis; 94.4% of whom had lung metastasis. Univariable analysis revealed sublingual or minor salivary gland, tumor size ≥2.5 cm, and perineural invasion as risk factors (hazard ratio [HR]: 1.99 [1.02–3.91], 2.57 [1.19–5.58], and 2.46 [1.28–4.74], respectively), whereas size, perineural invasion, and local recurrence were risk factors in multivariable analysis (HR: 2.29 [1.05–4.96], 2.32 [1.09–4.96], and 2.68 [1.24–5.79], respectively). Conclusion: Sublingual gland or minor salivary glands ACC has a higher risk of lung metastasis. If the site is not considered, the following factors increased the risk of lung metastasis; (a) size ≥2.5 cm, (b) perineural invasion, and (c) local recurrence.

Original languageEnglish
Pages (from-to)3976-3983
Number of pages8
JournalHead and Neck
Issue number11
StatePublished - 1 Nov 2019



  • head and neck neoplasm
  • neoplasm metastasis
  • risk factors
  • salivary glands

Cite this