Lung cancer in patients with idiopathic pulmonary fibrosis: Clinical characteristics and impact on survival

Taehoon Lee, Ji Young Park, Hong Yeul Lee, Young Jae Cho, Ho Il Yoon, Jae Ho Lee, Sanghoon Jheon, Choon Taek Lee, Jong Sun Park

Research output: Contribution to journalArticle

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Abstract

Background Idiopathic pulmonary fibrosis (IPF) is reportedly associated with an increased risk of lung cancer. However, few studies have explored whether IPF affects the long-term survival of lung cancer patients. The primary goal of this study was to evaluate the characteristics of lung cancer in IPF patients and impact of IPF on lung cancer survival. Methods Seventy IPF patients with histologically proven lung cancer were identified through a search of the Seoul National University Bundang Hospital database between 2003 and 2012. Of these, 33 patients who had undergone surgery were matched with 66 patients who had lung cancer without IPF. Matched variables included age, sex, histologic type, and lung cancer stage. Results Of the 70 subjects, 94% were male, and the mean age was 70 years (range, 46-90). In total, 81% of the tumors were located in the lung periphery, and 56% were in the lower lobe. The majority of cancers (70%) were observed in the fibrotic area on chest computed tomography scans. The most frequent histologic type was squamous cell carcinoma (40%). Among surgically treated patients (33 cases and 66 controls), the 5-year survival rates were 38% for lung cancer patients with IPF and 73% for those without IPF (p = 0.001). Conclusions Squamous cell carcinoma was the most common type of lung cancer in IPF patients. IPF reduced the survival of surgically treated lung cancer patients regardless of age, sex, histologic type, and/or lung cancer stage.

Original languageEnglish
Pages (from-to)1549-1555
Number of pages7
JournalRespiratory Medicine
Volume108
Issue number10
DOIs
StatePublished - 1 Oct 2014

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Idiopathic Pulmonary Fibrosis
Lung Neoplasms
Survival
Squamous Cell Carcinoma
Neoplasms
Thorax
Survival Rate
Tomography
Databases

Keywords

  • Idiopathic pulmonary fibrosis
  • Lung cancer
  • Survival

Cite this

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title = "Lung cancer in patients with idiopathic pulmonary fibrosis: Clinical characteristics and impact on survival",
abstract = "Background Idiopathic pulmonary fibrosis (IPF) is reportedly associated with an increased risk of lung cancer. However, few studies have explored whether IPF affects the long-term survival of lung cancer patients. The primary goal of this study was to evaluate the characteristics of lung cancer in IPF patients and impact of IPF on lung cancer survival. Methods Seventy IPF patients with histologically proven lung cancer were identified through a search of the Seoul National University Bundang Hospital database between 2003 and 2012. Of these, 33 patients who had undergone surgery were matched with 66 patients who had lung cancer without IPF. Matched variables included age, sex, histologic type, and lung cancer stage. Results Of the 70 subjects, 94{\%} were male, and the mean age was 70 years (range, 46-90). In total, 81{\%} of the tumors were located in the lung periphery, and 56{\%} were in the lower lobe. The majority of cancers (70{\%}) were observed in the fibrotic area on chest computed tomography scans. The most frequent histologic type was squamous cell carcinoma (40{\%}). Among surgically treated patients (33 cases and 66 controls), the 5-year survival rates were 38{\%} for lung cancer patients with IPF and 73{\%} for those without IPF (p = 0.001). Conclusions Squamous cell carcinoma was the most common type of lung cancer in IPF patients. IPF reduced the survival of surgically treated lung cancer patients regardless of age, sex, histologic type, and/or lung cancer stage.",
keywords = "Idiopathic pulmonary fibrosis, Lung cancer, Survival",
author = "Taehoon Lee and Park, {Ji Young} and Lee, {Hong Yeul} and Cho, {Young Jae} and Yoon, {Ho Il} and Lee, {Jae Ho} and Sanghoon Jheon and Lee, {Choon Taek} and Park, {Jong Sun}",
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Lung cancer in patients with idiopathic pulmonary fibrosis : Clinical characteristics and impact on survival. / Lee, Taehoon; Park, Ji Young; Lee, Hong Yeul; Cho, Young Jae; Yoon, Ho Il; Lee, Jae Ho; Jheon, Sanghoon; Lee, Choon Taek; Park, Jong Sun.

In: Respiratory Medicine, Vol. 108, No. 10, 01.10.2014, p. 1549-1555.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lung cancer in patients with idiopathic pulmonary fibrosis

T2 - Clinical characteristics and impact on survival

AU - Lee, Taehoon

AU - Park, Ji Young

AU - Lee, Hong Yeul

AU - Cho, Young Jae

AU - Yoon, Ho Il

AU - Lee, Jae Ho

AU - Jheon, Sanghoon

AU - Lee, Choon Taek

AU - Park, Jong Sun

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Background Idiopathic pulmonary fibrosis (IPF) is reportedly associated with an increased risk of lung cancer. However, few studies have explored whether IPF affects the long-term survival of lung cancer patients. The primary goal of this study was to evaluate the characteristics of lung cancer in IPF patients and impact of IPF on lung cancer survival. Methods Seventy IPF patients with histologically proven lung cancer were identified through a search of the Seoul National University Bundang Hospital database between 2003 and 2012. Of these, 33 patients who had undergone surgery were matched with 66 patients who had lung cancer without IPF. Matched variables included age, sex, histologic type, and lung cancer stage. Results Of the 70 subjects, 94% were male, and the mean age was 70 years (range, 46-90). In total, 81% of the tumors were located in the lung periphery, and 56% were in the lower lobe. The majority of cancers (70%) were observed in the fibrotic area on chest computed tomography scans. The most frequent histologic type was squamous cell carcinoma (40%). Among surgically treated patients (33 cases and 66 controls), the 5-year survival rates were 38% for lung cancer patients with IPF and 73% for those without IPF (p = 0.001). Conclusions Squamous cell carcinoma was the most common type of lung cancer in IPF patients. IPF reduced the survival of surgically treated lung cancer patients regardless of age, sex, histologic type, and/or lung cancer stage.

AB - Background Idiopathic pulmonary fibrosis (IPF) is reportedly associated with an increased risk of lung cancer. However, few studies have explored whether IPF affects the long-term survival of lung cancer patients. The primary goal of this study was to evaluate the characteristics of lung cancer in IPF patients and impact of IPF on lung cancer survival. Methods Seventy IPF patients with histologically proven lung cancer were identified through a search of the Seoul National University Bundang Hospital database between 2003 and 2012. Of these, 33 patients who had undergone surgery were matched with 66 patients who had lung cancer without IPF. Matched variables included age, sex, histologic type, and lung cancer stage. Results Of the 70 subjects, 94% were male, and the mean age was 70 years (range, 46-90). In total, 81% of the tumors were located in the lung periphery, and 56% were in the lower lobe. The majority of cancers (70%) were observed in the fibrotic area on chest computed tomography scans. The most frequent histologic type was squamous cell carcinoma (40%). Among surgically treated patients (33 cases and 66 controls), the 5-year survival rates were 38% for lung cancer patients with IPF and 73% for those without IPF (p = 0.001). Conclusions Squamous cell carcinoma was the most common type of lung cancer in IPF patients. IPF reduced the survival of surgically treated lung cancer patients regardless of age, sex, histologic type, and/or lung cancer stage.

KW - Idiopathic pulmonary fibrosis

KW - Lung cancer

KW - Survival

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DO - 10.1016/j.rmed.2014.07.020

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