Long-term (≥10 years) results of corneal endothelial cell loss after cataract surgery

Jung Yeol Choi, Young Keun Han

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To investigate the extent of long-term corneal endothelial loss after uneventful cataract surgery and the factors associated with decreases in corneal endothelial cell density (ECD). Design: Retrospective case series. Participants: Patients who had undergone uncomplicated cataract surgery. Methods: This study comprised 81 eyes of 48 patients who had undergone cataract surgery >10 years previously by a single surgeon with the same intraocular lens and visited the outpatient clinic between January 2014 and February 2017. Long-term (≥10 years) changes in visual outcome and ECD after uncomplicated cataract surgery were evaluated. To analyze factors correlated with endothelial cell loss, preoperative biometric variables, including cataract grade, anterior chamber depth, axial length, and postoperative corneal edema, were evaluated. Results: The mean ± SD preoperative and long-term postoperative ECD was 2793 ± 351.09 and 2148 ± 478.38 cells/mm2, respectively. The mean follow-up period was 11.08 ± 1.06 years and 10-year ECD loss rate was 20.62 ± 13.63%. Preoperative nuclear firmness was most statistically correlated with 10-year ECD loss (β-coefficient 0.394 [95% CI 3.402–9.448]; p < 0.001). The degree of postoperative corneal edema was also a significant predictive factor of 10-year ECD loss after cataract surgery (β-coefficient 0.378 [95% CI 2.854–8.358]; p = 0.002). Conclusion: Preoperative nuclear firmness and postoperative corneal edema were predictors of long-term (≥10 years) endothelial cell loss and severe endothelial cell loss after cataract surgery. It is important to remember that eyes with increased nuclear firmness have a significantly higher risk of long-term enhanced ECL.

Original languageEnglish
Pages (from-to)438-444
Number of pages7
JournalCanadian Journal of Ophthalmology
Volume54
Issue number4
DOIs
StatePublished - 1 Aug 2019

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Corneal Endothelial Cell Loss
Cataract
Endothelial Cells
Cell Count
Corneal Edema
Intraocular Lenses
Anterior Chamber
Ambulatory Care Facilities
Statistical Factor Analysis

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Choi, Jung Yeol ; Han, Young Keun. / Long-term (≥10 years) results of corneal endothelial cell loss after cataract surgery. In: Canadian Journal of Ophthalmology. 2019 ; Vol. 54, No. 4. pp. 438-444.
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Long-term (≥10 years) results of corneal endothelial cell loss after cataract surgery. / Choi, Jung Yeol; Han, Young Keun.

In: Canadian Journal of Ophthalmology, Vol. 54, No. 4, 01.08.2019, p. 438-444.

Research output: Contribution to journalArticleResearchpeer-review

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