Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: A case report

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Abstract

Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant hepatic hemangioma is frequently symptomatic, and requires intervention. Moreover, diffuse multiple hepatic hemangiomatosis occupying almost the entire liver is extremely rare in adults, and the optimal management for this condition is unclear. We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. This case shows malignant behavior of a benign hemangioma that required liver transplantation. Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. Further studies of the mechanism underlying hemangioma growth are warranted.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalClinical and Molecular Hepatology
Volume24
Issue number2
DOIs
StatePublished - 1 Jun 2018

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Living Donors
Hemangioma
Liver Transplantation
Liver
End Stage Liver Disease
Liver Neoplasms
Transplantation
Tissue Donors
Growth
Neoplasms

Keywords

  • Hemangioma
  • Hemangiomatosis
  • Hepatic neoplasm
  • Liver transplantation

Cite this

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title = "Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: A case report",
abstract = "Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant hepatic hemangioma is frequently symptomatic, and requires intervention. Moreover, diffuse multiple hepatic hemangiomatosis occupying almost the entire liver is extremely rare in adults, and the optimal management for this condition is unclear. We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. This case shows malignant behavior of a benign hemangioma that required liver transplantation. Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. Further studies of the mechanism underlying hemangioma growth are warranted.",
keywords = "Hemangioma, Hemangiomatosis, Hepatic neoplasm, Liver transplantation",
author = "Lee, {Ju Hyun} and Yoon, {Chang Jin} and Kim, {Young Hoon} and Ho-Seong Han and Cho, {Jai Young} and Haeryoung Kim and Jang, {Eun Sun} and Jin-Wook Kim and Sook-Hyang Jeong",
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T1 - Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult

T2 - A case report

AU - Lee, Ju Hyun

AU - Yoon, Chang Jin

AU - Kim, Young Hoon

AU - Han, Ho-Seong

AU - Cho, Jai Young

AU - Kim, Haeryoung

AU - Jang, Eun Sun

AU - Kim, Jin-Wook

AU - Jeong, Sook-Hyang

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant hepatic hemangioma is frequently symptomatic, and requires intervention. Moreover, diffuse multiple hepatic hemangiomatosis occupying almost the entire liver is extremely rare in adults, and the optimal management for this condition is unclear. We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. This case shows malignant behavior of a benign hemangioma that required liver transplantation. Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. Further studies of the mechanism underlying hemangioma growth are warranted.

AB - Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant hepatic hemangioma is frequently symptomatic, and requires intervention. Moreover, diffuse multiple hepatic hemangiomatosis occupying almost the entire liver is extremely rare in adults, and the optimal management for this condition is unclear. We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. This case shows malignant behavior of a benign hemangioma that required liver transplantation. Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. Further studies of the mechanism underlying hemangioma growth are warranted.

KW - Hemangioma

KW - Hemangiomatosis

KW - Hepatic neoplasm

KW - Liver transplantation

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