Lipid profile in patients with androgenetic alopecia

a meta-analysis

M. W. Kim, I. S. Shin, Hyun Sun Yoon, Soyun Cho, Hyun Sun Park

Research output: Contribution to journalReview articleResearchpeer-review

3 Citations (Scopus)

Abstract

Background: Many studies have reported that androgenetic alopecia (AGA) might be a risk factor for cardiovascular disorders, and the association of AGA with dyslipidaemia has been studied. However, the results were controversial and previous meta-analyses had several critical limitations. Objective: We performed a meta-analysis to clarify whether AGA patients have abnormal lipid profiles. Methods: A literature search was performed using the MEDLINE, EMBASE, The Cochrane Library and KOREA MED databases. Results: We pooled 19 observational studies and performed a meta-analysis to compare serum total cholesterol, serum triglyceride (TG), low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) and the cholesterol levels between AGA and control groups. The serum total cholesterol, TG and LDL cholesterol levels were significantly higher in the AGA group than in the control group, and the standardized mean differences were 0.377 (95% confidence interval [CI]: 0.182–0.572, P < 0.001), 0.426 (95% CI: 0.164–0.688, P = 0.001) and 0.450 (95% CI: 0.171–0.728, P = 0.002) respectively. In addition, HDL cholesterol level was significantly lower in the AGA group than in the control group, and the standardized mean difference was −0.248 (95% CI: −0.472 to −0.023, P = 0.030). Conclusions: AGA patients showed statistically significant abnormal lipid profiles, and this might partly explain the association between AGA and cardiovascular diseases.

Original languageEnglish
Pages (from-to)942-951
Number of pages10
JournalJournal of the European Academy of Dermatology and Venereology
Volume31
Issue number6
DOIs
StatePublished - 1 Jun 2017

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Alopecia
Meta-Analysis
Lipids
Confidence Intervals
LDL Cholesterol
Control Groups
HDL Cholesterol
Triglycerides
Serum
Cholesterol
Dyslipidemias
MEDLINE
Libraries
Observational Studies
Cardiovascular Diseases
Databases

Cite this

@article{bc8133df32af49659f596d7536aa7f1d,
title = "Lipid profile in patients with androgenetic alopecia: a meta-analysis",
abstract = "Background: Many studies have reported that androgenetic alopecia (AGA) might be a risk factor for cardiovascular disorders, and the association of AGA with dyslipidaemia has been studied. However, the results were controversial and previous meta-analyses had several critical limitations. Objective: We performed a meta-analysis to clarify whether AGA patients have abnormal lipid profiles. Methods: A literature search was performed using the MEDLINE, EMBASE, The Cochrane Library and KOREA MED databases. Results: We pooled 19 observational studies and performed a meta-analysis to compare serum total cholesterol, serum triglyceride (TG), low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) and the cholesterol levels between AGA and control groups. The serum total cholesterol, TG and LDL cholesterol levels were significantly higher in the AGA group than in the control group, and the standardized mean differences were 0.377 (95{\%} confidence interval [CI]: 0.182–0.572, P < 0.001), 0.426 (95{\%} CI: 0.164–0.688, P = 0.001) and 0.450 (95{\%} CI: 0.171–0.728, P = 0.002) respectively. In addition, HDL cholesterol level was significantly lower in the AGA group than in the control group, and the standardized mean difference was −0.248 (95{\%} CI: −0.472 to −0.023, P = 0.030). Conclusions: AGA patients showed statistically significant abnormal lipid profiles, and this might partly explain the association between AGA and cardiovascular diseases.",
author = "Kim, {M. W.} and Shin, {I. S.} and Yoon, {Hyun Sun} and Soyun Cho and Park, {Hyun Sun}",
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Lipid profile in patients with androgenetic alopecia : a meta-analysis. / Kim, M. W.; Shin, I. S.; Yoon, Hyun Sun; Cho, Soyun; Park, Hyun Sun.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 31, No. 6, 01.06.2017, p. 942-951.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Lipid profile in patients with androgenetic alopecia

T2 - a meta-analysis

AU - Kim, M. W.

AU - Shin, I. S.

AU - Yoon, Hyun Sun

AU - Cho, Soyun

AU - Park, Hyun Sun

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Many studies have reported that androgenetic alopecia (AGA) might be a risk factor for cardiovascular disorders, and the association of AGA with dyslipidaemia has been studied. However, the results were controversial and previous meta-analyses had several critical limitations. Objective: We performed a meta-analysis to clarify whether AGA patients have abnormal lipid profiles. Methods: A literature search was performed using the MEDLINE, EMBASE, The Cochrane Library and KOREA MED databases. Results: We pooled 19 observational studies and performed a meta-analysis to compare serum total cholesterol, serum triglyceride (TG), low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) and the cholesterol levels between AGA and control groups. The serum total cholesterol, TG and LDL cholesterol levels were significantly higher in the AGA group than in the control group, and the standardized mean differences were 0.377 (95% confidence interval [CI]: 0.182–0.572, P < 0.001), 0.426 (95% CI: 0.164–0.688, P = 0.001) and 0.450 (95% CI: 0.171–0.728, P = 0.002) respectively. In addition, HDL cholesterol level was significantly lower in the AGA group than in the control group, and the standardized mean difference was −0.248 (95% CI: −0.472 to −0.023, P = 0.030). Conclusions: AGA patients showed statistically significant abnormal lipid profiles, and this might partly explain the association between AGA and cardiovascular diseases.

AB - Background: Many studies have reported that androgenetic alopecia (AGA) might be a risk factor for cardiovascular disorders, and the association of AGA with dyslipidaemia has been studied. However, the results were controversial and previous meta-analyses had several critical limitations. Objective: We performed a meta-analysis to clarify whether AGA patients have abnormal lipid profiles. Methods: A literature search was performed using the MEDLINE, EMBASE, The Cochrane Library and KOREA MED databases. Results: We pooled 19 observational studies and performed a meta-analysis to compare serum total cholesterol, serum triglyceride (TG), low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) and the cholesterol levels between AGA and control groups. The serum total cholesterol, TG and LDL cholesterol levels were significantly higher in the AGA group than in the control group, and the standardized mean differences were 0.377 (95% confidence interval [CI]: 0.182–0.572, P < 0.001), 0.426 (95% CI: 0.164–0.688, P = 0.001) and 0.450 (95% CI: 0.171–0.728, P = 0.002) respectively. In addition, HDL cholesterol level was significantly lower in the AGA group than in the control group, and the standardized mean difference was −0.248 (95% CI: −0.472 to −0.023, P = 0.030). Conclusions: AGA patients showed statistically significant abnormal lipid profiles, and this might partly explain the association between AGA and cardiovascular diseases.

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U2 - 10.1111/jdv.14000

DO - 10.1111/jdv.14000

M3 - Review article

VL - 31

SP - 942

EP - 951

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

IS - 6

ER -