Leber's hereditary optic neuropathy mutations in ethambutol-induced optic neuropathy

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Abstract

Primary mitochondrial DNA (mtDNA) mutation at the nt 11778 site in Leber's hereditary optic neuropathy (LHON) has been reported to be present in patients with ethambutol-induced optic neuropathy. To study further this association between LHON and ethambutol-induced optic neuropathy, we tested ethambutol-induced optic neuropathy patients for the presence of the mtDNA mutations at nucleotides (nt)- 11778, nt- 14484, nt-3460, nt-15257, nt-9438, nt-9804, nt-13730, and nt- 14459 in 24, 15, 8, 6, 5, 5, 5, and 5 patients respectively. However, none of the ethambutol-induced optic neuropathy patients was found to exhibit any pathogenic LHON mtDNA mutation. In conclusion, we found no evidence of any association between ethambutol-induced optic neuropathy and the LHON mutations.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalJournal of Neurology
Volume250
Issue number1
DOIs
StatePublished - 1 Jan 2003

Keywords

  • Ethambutol
  • Leber's hereditary optic neuropathy
  • Mitochondrial DNA mutation
  • Toxic optic neuropathy

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