Isolation of multiple nontuberculous mycobacteria species in the same patients

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Abstract

Background: During the observation of many patients with nontuberculous mycobacteria (NTM) infections, we have often isolated different NTM species in the same patient. In this study we elucidated the patterns of multiple NTM species isolation. Methods: The analysis included all patients from whom more than one species of mycobacteria were cultured from a respiratory specimen at Seoul National University Hospital, a tertiary referral hospital in South Korea, between January 2002 and December 2008. The demographic characteristics and clinical and radiographic findings were reviewed retrospectively. Results: Multiple NTM species were isolated from 37 patients. Four patients with Mycobacterium gordonae, Mycobacterium terrae, or Mycobacterium lentiflavum were excluded due to the possibility of contamination. Transition to another NTM species was observed in 23 patients (69.7%), while alternating isolation of two or three NTM species was seen in nine patients. Two species were isolated simultaneously from different sputum samples collected from one patient on the same day. Conclusions: Different NTM species were isolated from the same patients.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume15
Issue number11
DOIs
StatePublished - 1 Nov 2011

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Nontuberculous Mycobacteria
Mycobacterium
Nontuberculous Mycobacterium Infections
Republic of Korea
Sputum
Tertiary Care Centers
Observation
Demography

Keywords

  • Multiple isolation
  • Mycobacterium abscessus
  • Mycobacterium avium-intracellulare
  • Nontuberculous mycobacteria

Cite this

@article{c39700355af741b9b5e8449e0aa12484,
title = "Isolation of multiple nontuberculous mycobacteria species in the same patients",
abstract = "Background: During the observation of many patients with nontuberculous mycobacteria (NTM) infections, we have often isolated different NTM species in the same patient. In this study we elucidated the patterns of multiple NTM species isolation. Methods: The analysis included all patients from whom more than one species of mycobacteria were cultured from a respiratory specimen at Seoul National University Hospital, a tertiary referral hospital in South Korea, between January 2002 and December 2008. The demographic characteristics and clinical and radiographic findings were reviewed retrospectively. Results: Multiple NTM species were isolated from 37 patients. Four patients with Mycobacterium gordonae, Mycobacterium terrae, or Mycobacterium lentiflavum were excluded due to the possibility of contamination. Transition to another NTM species was observed in 23 patients (69.7{\%}), while alternating isolation of two or three NTM species was seen in nine patients. Two species were isolated simultaneously from different sputum samples collected from one patient on the same day. Conclusions: Different NTM species were isolated from the same patients.",
keywords = "Multiple isolation, Mycobacterium abscessus, Mycobacterium avium-intracellulare, Nontuberculous mycobacteria",
author = "Lim, {Hyo Jeong} and Park, {Chang Min} and Park, {Young Sik} and Jinwoo Lee and Sang-Min Lee and Yang, {Seok Chul} and Yoo, {Chul Gyu} and Youngwhan Kim and Sungkoo Han and Jae-Joon Yim",
year = "2011",
month = "11",
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doi = "10.1016/j.ijid.2011.07.004",
language = "English",
volume = "15",
journal = "International Journal of Infectious Diseases",
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TY - JOUR

T1 - Isolation of multiple nontuberculous mycobacteria species in the same patients

AU - Lim, Hyo Jeong

AU - Park, Chang Min

AU - Park, Young Sik

AU - Lee, Jinwoo

AU - Lee, Sang-Min

AU - Yang, Seok Chul

AU - Yoo, Chul Gyu

AU - Kim, Youngwhan

AU - Han, Sungkoo

AU - Yim, Jae-Joon

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Background: During the observation of many patients with nontuberculous mycobacteria (NTM) infections, we have often isolated different NTM species in the same patient. In this study we elucidated the patterns of multiple NTM species isolation. Methods: The analysis included all patients from whom more than one species of mycobacteria were cultured from a respiratory specimen at Seoul National University Hospital, a tertiary referral hospital in South Korea, between January 2002 and December 2008. The demographic characteristics and clinical and radiographic findings were reviewed retrospectively. Results: Multiple NTM species were isolated from 37 patients. Four patients with Mycobacterium gordonae, Mycobacterium terrae, or Mycobacterium lentiflavum were excluded due to the possibility of contamination. Transition to another NTM species was observed in 23 patients (69.7%), while alternating isolation of two or three NTM species was seen in nine patients. Two species were isolated simultaneously from different sputum samples collected from one patient on the same day. Conclusions: Different NTM species were isolated from the same patients.

AB - Background: During the observation of many patients with nontuberculous mycobacteria (NTM) infections, we have often isolated different NTM species in the same patient. In this study we elucidated the patterns of multiple NTM species isolation. Methods: The analysis included all patients from whom more than one species of mycobacteria were cultured from a respiratory specimen at Seoul National University Hospital, a tertiary referral hospital in South Korea, between January 2002 and December 2008. The demographic characteristics and clinical and radiographic findings were reviewed retrospectively. Results: Multiple NTM species were isolated from 37 patients. Four patients with Mycobacterium gordonae, Mycobacterium terrae, or Mycobacterium lentiflavum were excluded due to the possibility of contamination. Transition to another NTM species was observed in 23 patients (69.7%), while alternating isolation of two or three NTM species was seen in nine patients. Two species were isolated simultaneously from different sputum samples collected from one patient on the same day. Conclusions: Different NTM species were isolated from the same patients.

KW - Multiple isolation

KW - Mycobacterium abscessus

KW - Mycobacterium avium-intracellulare

KW - Nontuberculous mycobacteria

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