Isoflavone and soyfood intake and colorectal cancer risk: A case-control study in Korea

Aesun Shin, Jeonghee Lee, Jeeyoo Lee, Moon Sung Park, Ji Won Park, Sung Chan Park, Jae Hwan Oh, Jeongseon Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We aimed to assess the relationship between dietary soyfood and isoflavone intake and colorectal cancer risk in a case-control study. A total of 901 colorectal cancer cases and 2669 controls were recruited at the National Cancer Center, Korea. A semi-quantitative food frequency questionnaire was used to assess the usual dietary habits, and the isoflavone intake level was estimated from five soyfood items. A high intake of total soy products, legumes, and sprouts was associated with a reduced risk for colorectal cancer in men and women, although the middle quartiles of intake of total soy products were associated with an elevated risk. In contrast, a high intake of fermented soy paste was associated with an elevated risk for colorectal cancer in men. The groups with the highest intake quartiles of isoflavones showed a decreased risk for colorectal cancer compared to their counterparts with the lowest intake quartiles in men (odds ratio (OR): 0.67, 95% confidence interval (CI): 0.51-0.89) and women (OR: 0.65, 95% CI: 0.43-0.99). The reduced risk for the highest intake groups persisted for distal colon cancer in men and rectal cancer in women. The association between soyfood intake and colorectal cancer risk was more prominent among post-menopausal women than pre-menopausal women. In conclusion, a high intake of total soy products or dietary isoflavones was associated with a reduced risk for overall colorectal cancer, and the association may be more relevant to distal colon or rectal cancers.

Original languageEnglish
Article numbere0143228
JournalPLoS ONE
Volume10
Issue number11
DOIs
StatePublished - 1 Nov 2015

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Isoflavones
Korea
isoflavones
case-control studies
colorectal neoplasms
Korean Peninsula
Case-Control Studies
Colorectal Neoplasms
soybean products
Rectal Neoplasms
Colonic Neoplasms
menopause
Odds Ratio
Confidence Intervals
odds ratio
confidence interval
Feeding Behavior
Ointments
Fabaceae
sprouts (food)

Cite this

Shin, Aesun ; Lee, Jeonghee ; Lee, Jeeyoo ; Park, Moon Sung ; Park, Ji Won ; Park, Sung Chan ; Oh, Jae Hwan ; Kim, Jeongseon. / Isoflavone and soyfood intake and colorectal cancer risk : A case-control study in Korea. In: PLoS ONE. 2015 ; Vol. 10, No. 11.
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abstract = "We aimed to assess the relationship between dietary soyfood and isoflavone intake and colorectal cancer risk in a case-control study. A total of 901 colorectal cancer cases and 2669 controls were recruited at the National Cancer Center, Korea. A semi-quantitative food frequency questionnaire was used to assess the usual dietary habits, and the isoflavone intake level was estimated from five soyfood items. A high intake of total soy products, legumes, and sprouts was associated with a reduced risk for colorectal cancer in men and women, although the middle quartiles of intake of total soy products were associated with an elevated risk. In contrast, a high intake of fermented soy paste was associated with an elevated risk for colorectal cancer in men. The groups with the highest intake quartiles of isoflavones showed a decreased risk for colorectal cancer compared to their counterparts with the lowest intake quartiles in men (odds ratio (OR): 0.67, 95{\%} confidence interval (CI): 0.51-0.89) and women (OR: 0.65, 95{\%} CI: 0.43-0.99). The reduced risk for the highest intake groups persisted for distal colon cancer in men and rectal cancer in women. The association between soyfood intake and colorectal cancer risk was more prominent among post-menopausal women than pre-menopausal women. In conclusion, a high intake of total soy products or dietary isoflavones was associated with a reduced risk for overall colorectal cancer, and the association may be more relevant to distal colon or rectal cancers.",
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Isoflavone and soyfood intake and colorectal cancer risk : A case-control study in Korea. / Shin, Aesun; Lee, Jeonghee; Lee, Jeeyoo; Park, Moon Sung; Park, Ji Won; Park, Sung Chan; Oh, Jae Hwan; Kim, Jeongseon.

In: PLoS ONE, Vol. 10, No. 11, e0143228, 01.11.2015.

Research output: Contribution to journalArticle

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