Is There a Link between Expression Levels of Histone Deacetylase/Acetyltransferase in Mouse Sperm and Subsequent Blastocyst Development?

Jayeon Kim, Ji Hee Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim

Research output: Contribution to journalArticle

Abstract

Histone acetylation has been known to be significant in spermatogenesis. Histone acetylation is regulated by the act of histone deacetylases (HDACs) and histone acetyltransferases (HATs). We investigated the link between expression levels of HDACs and HATs in mouse sperm and subsequent blastocyst formation rate. In the univariate analysis, expression levels of HDAC1 and HAT were generally not associated with the blastocyst formation rate. When divided by the mature oocyte number category, a significant positive association was observed between the expression levels of HDAC1 and the blastocyst-forming rate in the highest (> 75th) percentile group (a group with ≥34 mature oocytes). In conclusion, expression of sperm HDAC1 could be considered as a possible predictor of embryo development in mice with high ovarian response.

Original languageEnglish
Pages (from-to)1387-1392
Number of pages6
JournalReproductive Sciences
Volume22
Issue number11
DOIs
StatePublished - 1 Nov 2015

Keywords

  • blastocyst
  • histone acetylation
  • histone deacetylase
  • mouse
  • sperm

Cite this