Intratumoral mast cell number is negatively correlated with tumor size and mitosis in dermatofibrosarcoma protuberans

Minji Kim, Kwang Hyun Cho, Jong Hee Lee, Mee Soo Chang, Soyun Cho

Research output: Contribution to journalLetterResearchpeer-review

5 Citations (Scopus)

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor with intermediate malignancy. The purpose of this study was to evaluate the utility of p53, smooth muscle actin (SMA) and c-kit as immunohistochemical markers and toluidine blue staining for mast cell that can correlate with the clinical outcome and clarify role of mast cells in pathogenesis of tumor. We analysed data for 32 lesions from 31 patients. Fibrosarcomatous type DFSP showed high immunoreactivity for SMA compared with other subtypes (P = 0.026). No differences in p53 immunoreactivity were observed between subtypes. None of tumor cells were immunoreactive with c-kit. The mast cell counts showed a negative correlation with mitosis and tumor size (P < 0.05), implying that mast cells do not have a causative primary role in tumorigenesis but rather play a secondary role.

Original languageEnglish
Pages (from-to)559-561
Number of pages3
JournalExperimental Dermatology
Volume21
Issue number7
DOIs
StatePublished - 1 Jul 2012

Fingerprint

Dermatofibrosarcoma
Mitosis
Mast Cells
Tumors
Cell Count
Muscle
Actins
Neoplasms
Smooth Muscle
Tolonium Chloride
Cells
Carcinogenesis
Staining and Labeling
Skin

Keywords

  • C-kit
  • Dermatofibrosarcoma protuberans
  • Mast cell
  • P-53
  • Smooth muscle actin

Cite this

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title = "Intratumoral mast cell number is negatively correlated with tumor size and mitosis in dermatofibrosarcoma protuberans",
abstract = "Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor with intermediate malignancy. The purpose of this study was to evaluate the utility of p53, smooth muscle actin (SMA) and c-kit as immunohistochemical markers and toluidine blue staining for mast cell that can correlate with the clinical outcome and clarify role of mast cells in pathogenesis of tumor. We analysed data for 32 lesions from 31 patients. Fibrosarcomatous type DFSP showed high immunoreactivity for SMA compared with other subtypes (P = 0.026). No differences in p53 immunoreactivity were observed between subtypes. None of tumor cells were immunoreactive with c-kit. The mast cell counts showed a negative correlation with mitosis and tumor size (P < 0.05), implying that mast cells do not have a causative primary role in tumorigenesis but rather play a secondary role.",
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Intratumoral mast cell number is negatively correlated with tumor size and mitosis in dermatofibrosarcoma protuberans. / Kim, Minji; Cho, Kwang Hyun; Lee, Jong Hee; Chang, Mee Soo; Cho, Soyun.

In: Experimental Dermatology, Vol. 21, No. 7, 01.07.2012, p. 559-561.

Research output: Contribution to journalLetterResearchpeer-review

TY - JOUR

T1 - Intratumoral mast cell number is negatively correlated with tumor size and mitosis in dermatofibrosarcoma protuberans

AU - Kim, Minji

AU - Cho, Kwang Hyun

AU - Lee, Jong Hee

AU - Chang, Mee Soo

AU - Cho, Soyun

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AB - Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor with intermediate malignancy. The purpose of this study was to evaluate the utility of p53, smooth muscle actin (SMA) and c-kit as immunohistochemical markers and toluidine blue staining for mast cell that can correlate with the clinical outcome and clarify role of mast cells in pathogenesis of tumor. We analysed data for 32 lesions from 31 patients. Fibrosarcomatous type DFSP showed high immunoreactivity for SMA compared with other subtypes (P = 0.026). No differences in p53 immunoreactivity were observed between subtypes. None of tumor cells were immunoreactive with c-kit. The mast cell counts showed a negative correlation with mitosis and tumor size (P < 0.05), implying that mast cells do not have a causative primary role in tumorigenesis but rather play a secondary role.

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KW - Smooth muscle actin

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