Intraoperative botulinum toxin injection for superficial partial parotidectomy: A prospective pilot study

Dong Joo Lee, Yu Mi Lee, Hye Jin Park, Jung Woo Lee, Wonjae Cha

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Sialocele and salivary fistula are not serious but troublesome complications after parotidectomy. Various modalities have been introduced to prevent postoperative saliva-related complications. However, clinical trials assessing the prophylactic use of botulinum toxin (BTX) for parotidectomy have not been conducted yet. Herein, we report a pilot study investigating the safety and efficacy of intraoperative BTX (iBTX) injection in partial superficial parotidectomy (PSP). Participants: Patients with benign parotid tumour were prospectively recruited for this clinical trial from 2017 to 2019. The study participants underwent PSP with iBTX injection. We retrospectively reviewed the clinical information of all the consecutive patients who underwent PSP without iBTX from 2013 to 2019. These patients were divided into two groups: the iBTX group (n = 36) and the control group (n = 54). Results: Permanent facial palsy was not observed in either group. Two patients (3.7%) had transient marginal palsy in the control group but none had it in the iBTX group. The incidence of sialocele was significantly lower in the iBTX group than in the control group (2.8% vs. 20.4%, P <.05). Although the incidence of salivary fistula was lower in the iBTX group than in the control group (0% vs. 7.4%), no significant difference was determined between the two groups (P =.147). Total drainage volume was significantly lower in the iBTX group than in the control group (55.0 mL vs. 116.6 mL, P <.001). Conclusions: iBTX injection may be safe and effective in reducing sialocele and postoperative drainage in PSP. It might be a useful option to prevent saliva-related complications after PSP.

Original languageEnglish
Pages (from-to)998-1004
Number of pages7
JournalClinical Otolaryngology
Volume46
Issue number5
DOIs
StatePublished - Sep 2021

Keywords

  • botulinum toxin
  • intraoperative
  • parotid tumour
  • parotidectomy
  • salivary fistula
  • sialocele

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