Intrahepatic Mass-Forming Cholangiocarcinoma: Relationship between Computed Tomography Characteristics and Histological Subtypes

Ju Gang Nam, Jeong Min Lee, Ijin Joo, Su Joa Ahn, Jin Young Park, Kyoung Bun Lee, Joon Koo Han

Research output: Contribution to journalArticle

3 Scopus citations


Objective The aim of this study was to determine the value of multi-detector row computed tomography (MDCT) in differentiating the small-duct (SD) and large-duct (LD) types of intrahepatic mass-forming cholangiocarcinomas (IMCCs) and predicting patient prognosis. Methods The 4-phase MDCT image findings of 82 patients with surgically confirmed IMCCs (60 SD-type and 22 LD-type IMCCs) were compared between 2 types using univariate and multivariate analyses. Overall survival rates for 78 patients with available information were compared using the Kaplan-Meier method. Results Arterial hyperenhancement, round or lobulated contour, and lack of bile duct encasement were significant MDCT features suggesting the SD type, and lymph node enlargement was significantly associated with the LD type (all P's < 0.05). The presence of those 3 SD-type-suggestive features (MDCT-suggested SD type) demonstrated high specificity (90.9% [20/22]) in differentiating the SD type. Patients of MDCT-suggested SD type without lymph node enlargement (n = 24) demonstrated significantly better overall survival than other groups. Conclusions Preoperative MDCT features of IMCCs can help differentiate the SD and LD types and predict patient prognosis.

Original languageEnglish
Pages (from-to)340-349
Number of pages10
JournalJournal of computer assisted tomography
Issue number3
StatePublished - 1 May 2018


  • CT
  • intrahepatic cholangiocarcinoma
  • large duct
  • liver
  • prognostic value
  • small duct

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