La degradación intracelular de proteínas. desde una vaga idea, a través del lisosoma y el sistema ubiquitina-proteosoma a las enfermedades humanas y el blanco de las drogas

Translated title of the contribution: Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Between the 1950s and 1980s, scientists were focusing mostly on how the genetic code is transcribed to RNA and translated to proteins, but how proteins are degraded has remained a neglected research area. With the discovery of the lysosome by Christian de Duve it was assumed that cellular proteins are degraded within this organelle. Yet, several independent lines of experimental evidence strongly suggested that intracellular proteolysis is largely non-lysosomal, but the mechanisms involved remained obscure. The discovery of the ubiquitin-proteasome system resolved the enigma. We now recognize that degradation of intracellular proteins is involved in regulation of a broad array of cellular processes, such as cell cycle and division, regulation of transcription factors, and assurance of the cellular quality control. Not surprisingly, aberrations in the system have been implicated in the pathogenesis of human disease, such as malignancies and neurodegenerative disorders, which led subsequently to an increasing effort to develop mechanism-based drugs.

Original languageSpanish
Pages (from-to)105-119
Number of pages15
JournalMedicina
Volume70
Issue number2
StatePublished - 1 Dec 2010

Fingerprint

Proteasome Endopeptidase Complex
Drug Delivery Systems
Ubiquitin
Lysosomes
Proteolysis
Genetic Code
Proteins
Neurodegenerative Diseases
Quality Control
Organelles
Cell Cycle
Transcription Factors
RNA
Research
Pharmaceutical Preparations
Neoplasms

Keywords

  • Disease
  • Drug design
  • Proteasome
  • Ubiquitin

Cite this

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title = "La degradaci{\'o}n intracelular de prote{\'i}nas. desde una vaga idea, a trav{\'e}s del lisosoma y el sistema ubiquitina-proteosoma a las enfermedades humanas y el blanco de las drogas",
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