Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes

Kyung Joon Oh, Kyung A. Lee, Yoo Kyung Sohn, Chan-Wook Park, Joon Seok Hong, Roberto Romero, Bohyun Yoon

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Abstract

Objective: The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms. Study Design: We examined the intensity of intraamniotic and maternal inflammatory responses in 99 patients with preterm premature rupture of membranes and a positive amniotic fluid (AF) culture. AF was obtained by transabdominal amniocentesis or at the time of cesarean delivery. Patients were divided according to the recovered microorganisms: (1) genital mycoplasmas (n = 62); (2) other microorganisms (n = 31); or (3) mixed infection (n = 6). Results: The median AF white blood cell (WBC) count, maternal blood WBC count, and plasma C-reactive protein concentrations were significantly higher in patients with intraamniotic infection with genital mycoplasmas than in those with intraamniotic infection with other microorganisms (P < .05 for each). Conclusion: Intraamniotic and maternal inflammatory responses are more intense in intraamniotic infection with genital mycoplasmas than in intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.

Original languageEnglish
Pages (from-to)211.e1-211.e8
JournalAmerican Journal of Obstetrics and Gynecology
Volume203
Issue number3
DOIs
StatePublished - 1 Jan 2010

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Mycoplasma
Amniotic Fluid
Infection
Mothers
Leukocyte Count
Mycoplasma Infections
Amniocentesis
Coinfection
C-Reactive Protein
Blood Proteins
Preterm Premature Rupture of the Membranes

Keywords

  • CRP
  • IL-6
  • chorioamnionitis
  • interleukin-6
  • intraamniotic inflammation
  • mycoplasmas
  • preterm birth
  • ureaplasma

Cite this

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title = "Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes",
abstract = "Objective: The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms. Study Design: We examined the intensity of intraamniotic and maternal inflammatory responses in 99 patients with preterm premature rupture of membranes and a positive amniotic fluid (AF) culture. AF was obtained by transabdominal amniocentesis or at the time of cesarean delivery. Patients were divided according to the recovered microorganisms: (1) genital mycoplasmas (n = 62); (2) other microorganisms (n = 31); or (3) mixed infection (n = 6). Results: The median AF white blood cell (WBC) count, maternal blood WBC count, and plasma C-reactive protein concentrations were significantly higher in patients with intraamniotic infection with genital mycoplasmas than in those with intraamniotic infection with other microorganisms (P < .05 for each). Conclusion: Intraamniotic and maternal inflammatory responses are more intense in intraamniotic infection with genital mycoplasmas than in intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.",
keywords = "CRP, IL-6, chorioamnionitis, interleukin-6, intraamniotic inflammation, mycoplasmas, preterm birth, ureaplasma",
author = "Oh, {Kyung Joon} and Lee, {Kyung A.} and Sohn, {Yoo Kyung} and Chan-Wook Park and Hong, {Joon Seok} and Roberto Romero and Bohyun Yoon",
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AU - Oh, Kyung Joon

AU - Lee, Kyung A.

AU - Sohn, Yoo Kyung

AU - Park, Chan-Wook

AU - Hong, Joon Seok

AU - Romero, Roberto

AU - Yoon, Bohyun

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N2 - Objective: The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms. Study Design: We examined the intensity of intraamniotic and maternal inflammatory responses in 99 patients with preterm premature rupture of membranes and a positive amniotic fluid (AF) culture. AF was obtained by transabdominal amniocentesis or at the time of cesarean delivery. Patients were divided according to the recovered microorganisms: (1) genital mycoplasmas (n = 62); (2) other microorganisms (n = 31); or (3) mixed infection (n = 6). Results: The median AF white blood cell (WBC) count, maternal blood WBC count, and plasma C-reactive protein concentrations were significantly higher in patients with intraamniotic infection with genital mycoplasmas than in those with intraamniotic infection with other microorganisms (P < .05 for each). Conclusion: Intraamniotic and maternal inflammatory responses are more intense in intraamniotic infection with genital mycoplasmas than in intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.

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