Intra-amniotic infection/inflammation as a risk factor for subsequent ruptured membranes after clinically indicated amniocentesis in preterm labor

Sung Youn Lee, Kyo Hoon Park, Eun Ha Jeong, Kyung Joon Oh, Aeli Ryu, Ahra Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI)was associated with subsequent ruptured membranes in women with preterm labor andintact membranes who had a clinically indicated amniocentesis. This retrospective cohortstudy included 237 consecutive women with preterm labor (20-34.6 weeks) whounderwent amniocentesis. The clinical and laboratory parameters evaluated includeddemographic variables, gestational age, C-reactive protein (CRP) and amniotic fluid (AF)white blood cell, interleukin-6 (IL-6) and culture results. IAI was defined as a positive AFculture and/or an elevated AF IL-6 level (> 2.6 ng/mL). The primary outcome was rupturedmembranes in the absence of active labor occurring within 48 hours of amniocentesis.Preterm premature rupture of membranes subsequently developed in 10 (4.2%) womenwithin 48 hr of amniocentesis. Multivariate analysis demonstrated that only IAI wasindependently associated with the ruptured membranes occurring within 48 hr ofamniocentesis. In the predictive model based on variables assessed before amniocentesis,only CRP level was retained. IAI is an independent risk factor for subsequent rupturedmembranes after clinically indicated amniocentesis in preterm labor. Prior to amniocentesis,measurement of serum CRP level can provide a risk assessment for the subsequentdevelopment of ruptured membranes after the procedure.

Original languageEnglish
Pages (from-to)1226-1232
Number of pages7
JournalJournal of Korean Medical Science
Volume28
Issue number8
DOIs
StatePublished - 25 Sep 2013

Fingerprint

Amniocentesis
Premature Obstetric Labor
Inflammation
Membranes
Infection
C-Reactive Protein
Amniotic Fluid
Interleukin-6
Gestational Age
Blood Proteins
Leukocytes
Multivariate Analysis

Keywords

  • Amniocentesis
  • C-reactive protein
  • Intra-amniotic infection/inflammation
  • Obstetric labor
  • Premature
  • Ruptured membranes

Cite this

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title = "Intra-amniotic infection/inflammation as a risk factor for subsequent ruptured membranes after clinically indicated amniocentesis in preterm labor",
abstract = "The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI)was associated with subsequent ruptured membranes in women with preterm labor andintact membranes who had a clinically indicated amniocentesis. This retrospective cohortstudy included 237 consecutive women with preterm labor (20-34.6 weeks) whounderwent amniocentesis. The clinical and laboratory parameters evaluated includeddemographic variables, gestational age, C-reactive protein (CRP) and amniotic fluid (AF)white blood cell, interleukin-6 (IL-6) and culture results. IAI was defined as a positive AFculture and/or an elevated AF IL-6 level (> 2.6 ng/mL). The primary outcome was rupturedmembranes in the absence of active labor occurring within 48 hours of amniocentesis.Preterm premature rupture of membranes subsequently developed in 10 (4.2{\%}) womenwithin 48 hr of amniocentesis. Multivariate analysis demonstrated that only IAI wasindependently associated with the ruptured membranes occurring within 48 hr ofamniocentesis. In the predictive model based on variables assessed before amniocentesis,only CRP level was retained. IAI is an independent risk factor for subsequent rupturedmembranes after clinically indicated amniocentesis in preterm labor. Prior to amniocentesis,measurement of serum CRP level can provide a risk assessment for the subsequentdevelopment of ruptured membranes after the procedure.",
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Intra-amniotic infection/inflammation as a risk factor for subsequent ruptured membranes after clinically indicated amniocentesis in preterm labor. / Lee, Sung Youn; Park, Kyo Hoon; Jeong, Eun Ha; Oh, Kyung Joon; Ryu, Aeli; Kim, Ahra.

In: Journal of Korean Medical Science, Vol. 28, No. 8, 25.09.2013, p. 1226-1232.

Research output: Contribution to journalArticle

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T1 - Intra-amniotic infection/inflammation as a risk factor for subsequent ruptured membranes after clinically indicated amniocentesis in preterm labor

AU - Lee, Sung Youn

AU - Park, Kyo Hoon

AU - Jeong, Eun Ha

AU - Oh, Kyung Joon

AU - Ryu, Aeli

AU - Kim, Ahra

PY - 2013/9/25

Y1 - 2013/9/25

N2 - The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI)was associated with subsequent ruptured membranes in women with preterm labor andintact membranes who had a clinically indicated amniocentesis. This retrospective cohortstudy included 237 consecutive women with preterm labor (20-34.6 weeks) whounderwent amniocentesis. The clinical and laboratory parameters evaluated includeddemographic variables, gestational age, C-reactive protein (CRP) and amniotic fluid (AF)white blood cell, interleukin-6 (IL-6) and culture results. IAI was defined as a positive AFculture and/or an elevated AF IL-6 level (> 2.6 ng/mL). The primary outcome was rupturedmembranes in the absence of active labor occurring within 48 hours of amniocentesis.Preterm premature rupture of membranes subsequently developed in 10 (4.2%) womenwithin 48 hr of amniocentesis. Multivariate analysis demonstrated that only IAI wasindependently associated with the ruptured membranes occurring within 48 hr ofamniocentesis. In the predictive model based on variables assessed before amniocentesis,only CRP level was retained. IAI is an independent risk factor for subsequent rupturedmembranes after clinically indicated amniocentesis in preterm labor. Prior to amniocentesis,measurement of serum CRP level can provide a risk assessment for the subsequentdevelopment of ruptured membranes after the procedure.

AB - The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI)was associated with subsequent ruptured membranes in women with preterm labor andintact membranes who had a clinically indicated amniocentesis. This retrospective cohortstudy included 237 consecutive women with preterm labor (20-34.6 weeks) whounderwent amniocentesis. The clinical and laboratory parameters evaluated includeddemographic variables, gestational age, C-reactive protein (CRP) and amniotic fluid (AF)white blood cell, interleukin-6 (IL-6) and culture results. IAI was defined as a positive AFculture and/or an elevated AF IL-6 level (> 2.6 ng/mL). The primary outcome was rupturedmembranes in the absence of active labor occurring within 48 hours of amniocentesis.Preterm premature rupture of membranes subsequently developed in 10 (4.2%) womenwithin 48 hr of amniocentesis. Multivariate analysis demonstrated that only IAI wasindependently associated with the ruptured membranes occurring within 48 hr ofamniocentesis. In the predictive model based on variables assessed before amniocentesis,only CRP level was retained. IAI is an independent risk factor for subsequent rupturedmembranes after clinically indicated amniocentesis in preterm labor. Prior to amniocentesis,measurement of serum CRP level can provide a risk assessment for the subsequentdevelopment of ruptured membranes after the procedure.

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KW - Obstetric labor

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