Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

Sin Young Ham, Hyungul Jung, Kyoung Ho Song, Hyeonju Jeong, Jongtak Jung, Song Mi Moon, Jeong Su Park, Nak Hyun Kim, Eun Sun Jang, Jin Wook Kim, Sook Hyang Jeong, Eu Suk Kim, Hong Bin Kim

Research output: Contribution to journalArticlepeer-review

Abstract

This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.

Original languageEnglish
Pages (from-to)1459-1465
Number of pages7
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume41
Issue number12
DOIs
StatePublished - Dec 2022

Keywords

  • Bloodstream infection
  • Enterobacteriaceae
  • Interspecies difference
  • Liver cirrhosis
  • Mortality
  • Third-generation cephalosporin resistance

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