Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

Sin Young Ham; Hyungul Jung; Kyoung Ho Song; Hyeonju Jeong; Jongtak Jung; Song Mi Moon; Jeong Su Park; Nak Hyun Kim; Eun Sun Jang; Jin Wook Kim; Sook Hyang Jeong; Eu Suk Kim; Hong Bin Kim

doi:10.1007/s10096-022-04508-2

Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

Sin Young Ham, Hyungul Jung, Kyoung Ho Song, Hyeonju Jeong, Jongtak Jung, Song Mi Moon, Jeong Su Park, Nak Hyun Kim, Eun Sun Jang, Jin Wook Kim, Sook Hyang Jeong, Eu Suk Kim, Hong Bin Kim

Research output: Contribution to journal › Article › peer-review

Abstract

This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.

Original language	English
Pages (from-to)	1459-1465
Number of pages	7
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	41
Issue number	12
DOIs	https://doi.org/10.1007/s10096-022-04508-2
State	Published - Dec 2022

Keywords

Bloodstream infection
Enterobacteriaceae
Interspecies difference
Liver cirrhosis
Mortality
Third-generation cephalosporin resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Ham, S. Y., Jung, H., Song, K. H., Jeong, H., Jung, J., Moon, S. M., Park, J. S., Kim, N. H., Jang, E. S., Kim, J. W., Jeong, S. H., Kim, E. S., & Kim, H. B. (2022). Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis. European Journal of Clinical Microbiology and Infectious Diseases, 41(12), 1459-1465. https://doi.org/10.1007/s10096-022-04508-2

Ham, Sin Young ; Jung, Hyungul ; Song, Kyoung Ho et al. / Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis. In: European Journal of Clinical Microbiology and Infectious Diseases. 2022 ; Vol. 41, No. 12. pp. 1459-1465.

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title = "Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis",

abstract = "This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.",

keywords = "Bloodstream infection, Enterobacteriaceae, Interspecies difference, Liver cirrhosis, Mortality, Third-generation cephalosporin resistance",

author = "Ham, {Sin Young} and Hyungul Jung and Song, {Kyoung Ho} and Hyeonju Jeong and Jongtak Jung and Moon, {Song Mi} and Park, {Jeong Su} and Kim, {Nak Hyun} and Jang, {Eun Sun} and Kim, {Jin Wook} and Jeong, {Sook Hyang} and Kim, {Eu Suk} and Kim, {Hong Bin}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

month = dec,

doi = "10.1007/s10096-022-04508-2",

language = "English",

volume = "41",

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Ham, SY, Jung, H, Song, KH, Jeong, H, Jung, J, Moon, SM, Park, JS, Kim, NH , Jang, ES , Kim, JW , Jeong, SH , Kim, ES & Kim, HB 2022, 'Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis', European Journal of Clinical Microbiology and Infectious Diseases, vol. 41, no. 12, pp. 1459-1465. https://doi.org/10.1007/s10096-022-04508-2

Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis. / Ham, Sin Young; Jung, Hyungul; Song, Kyoung Ho et al.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 41, No. 12, 12.2022, p. 1459-1465.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

AU - Ham, Sin Young

AU - Jung, Hyungul

AU - Song, Kyoung Ho

AU - Jeong, Hyeonju

AU - Jung, Jongtak

AU - Moon, Song Mi

AU - Park, Jeong Su

AU - Kim, Nak Hyun

AU - Jang, Eun Sun

AU - Kim, Jin Wook

AU - Jeong, Sook Hyang

AU - Kim, Eu Suk

AU - Kim, Hong Bin

PY - 2022/12

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N2 - This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.

AB - This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.

KW - Bloodstream infection

KW - Enterobacteriaceae

KW - Interspecies difference

KW - Liver cirrhosis

KW - Mortality

KW - Third-generation cephalosporin resistance

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JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

IS - 12

ER -

Ham SY, Jung H, Song KH, Jeong H, Jung J, Moon SM et al. Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis. European Journal of Clinical Microbiology and Infectious Diseases. 2022 Dec;41(12):1459-1465. doi: 10.1007/s10096-022-04508-2

Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

Abstract

Keywords

UN SDGs

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